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The Impact of Free Fatty Acid Reduction on Vascular Function in the Metabolic Syndrome

Metabolic Syndrome Clinical Trial

Official title:
The Impact of Free Fatty Acid Reduction on Vascular Function in the Metabolic Syndrome

Clinical Trial Summary

This study will test the hypothesis that reducing the release of free fatty acids (FFA) from fat cells will restore insulin-mediated, endothelium-dependent vasodilation in people with the metabolic syndrome.

Clinical Trial Description

We hypothesize that acipimox, by decreasing plasma FFA concentrations, will augment endothelium-dependent vasodilation in conduit vessels and insulin-mediated vasodilation in forearm resistance arterioles in vivo, whole-body insulin sensitivity, and AKT (also known as Protein Kinase B) and endothelial nitric oxide synthase (eNOS) phosphorylation in skin biopsy specimens ex vivo, when compared with placebo. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00759291
Study type Interventional
Source Brigham and Women's Hospital
Contact
Status Completed
Phase Phase 2/Phase 3
Start date April 1, 2006
Completion date December 30, 2017
View Details
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