Metabolic Disturbance Clinical Trial
— PAH-ProMetGenOfficial title:
Biological Signatures (Proteomics, Metabolomics and Genotoxicity) Associated With Occupational Exposure to PAH Mixtures and Relation With Exposure Biomarkers: Support for the Derivation of Biological Limit Values
This research project aims at better understanding the early biological effects resulting from occupational exposure to complex Polycyclic Aromatic Hydrocarbon (PAH) mixtures. Current biomarkers used as part of biomonitoring campaigns are biomarkers of exposure, not numerous and poorly related to health effects. The aim of this study is thus to improve our understanding of biological consequences of such exposures, both in terms of proteins deregulation, metabolism deregulation and genotoxicity.
Status | Recruiting |
Enrollment | 100 |
Est. completion date | October 2025 |
Est. primary completion date | October 2025 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Subjects ages 18 years or more - Subjects occupationally exposed to PAHs since more than 3 months - Having signed the informed consent - recruited by the occupational health service Exclusion Criteria: - Obesity (BMI>30) - Subjects suffering cancers or metabolic diseases (diabetes, dyslipidemia, amino-acid diseases, renal or hepatic impairment) at the onset of the study. - Subjects taking medications related to the above diseases at the onset of the study. |
Country | Name | City | State |
---|---|---|---|
France | CHU Grenoble Alpes | Grenoble |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Grenoble |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Deregulation of blood proteins expression due to exposure to PAHs | Number of proteins up or down regulated in period of exposure versus after holidays | up to 6 months between both periods of study | |
Primary | Deregulation of blood metabolites expression due to exposure to PAHs | Number of metabolites up or down regulated in period of exposure versus after holidays | up to 6 months between both periods of study | |
Primary | Frequency of micronuclei measured due to exposure to PAHs | Frequency of cells containing micronuclei in period of exposure versus after holidays | up to 6 months between both periods of study |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT04528004 -
Mechanistic Studies of Nicotinamide Riboside in Human Heart Failure
|
Early Phase 1 | |
Completed |
NCT04597983 -
Effect of 8-week Intake of 2S-hesperidin on Performance, Body Composition and Biochemicals Markers in Amateur Cyclists
|
N/A | |
Completed |
NCT03445234 -
Blueberries, Bananas, Exercise Recovery
|
N/A | |
Recruiting |
NCT04892199 -
Does GLP-1RA Prevent Deterioration of Metabolic State in Prediabetic and Diabetic Patients Treated With Antipsychotic Medication?
|
Phase 4 | |
Active, not recruiting |
NCT05070585 -
Isothiocyanates and Metabolic Health
|
Phase 1/Phase 2 | |
Not yet recruiting |
NCT05494151 -
Metabolic Substrate of Patients With Myocardial Infarction With and Without Modifiable Cardiovascular Risk Factors
|
||
Completed |
NCT04787952 -
Insight Into New Brown Adipose Tissue Activators.
|
||
Completed |
NCT05758857 -
Multiple Risk Factor Intervention Trial
|
N/A | |
Completed |
NCT02689882 -
"Pharmacokinetic Study of Nicotinamide Riboside"
|
Phase 1 | |
Completed |
NCT01674426 -
Pathogenesis of Functional Hypothalamic Amenorrhea
|
N/A | |
Recruiting |
NCT06252922 -
Diet-Induced Changes in GEnetic Material
|
||
Completed |
NCT06326840 -
Clinical Efficacy and Adverse Reactions of Antipsychotic Treatment
|
N/A | |
Recruiting |
NCT06345937 -
Multiple Risk Factor Intervention Trial (Ms. FIT)
|
N/A | |
Recruiting |
NCT06392360 -
Betaine, Exercise Performance, and Gut Permeability
|
N/A | |
Completed |
NCT04009642 -
Cardiac Rest and Stress Metabolism in Patients With Type 2 Diabetes
|
||
Withdrawn |
NCT03515642 -
Exercise, Gut Microbiota in Sedentary Adults With Overweight
|
N/A | |
Recruiting |
NCT06333184 -
Smoothies and Blood Sugars
|
N/A | |
Not yet recruiting |
NCT05773183 -
Exploring the Relationship Between Androgen Metabolism, Metabolic Disease and Skeletal Muscle Energy Balance in Men
|
||
Completed |
NCT04266665 -
Effect of Dexmedetomidine on Brain Homeostasis and Neurocognitive Outcome
|
Phase 4 | |
Completed |
NCT03697928 -
Markers of Carnitine Acetyltransferase (CrAT) Protein Activity and Carnitine Availability
|