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Markers of Carnitine Acetyltransferase (CrAT) Protein Activity and Carnitine Availability

Metabolic Disturbance Clinical Trial

Official title:
Searching for Non-invasive Magnetic Resonance-based Markers for CrAT Protein Activity and Carnitine Availability in Skeletal Muscle

Clinical Trial Summary

This study aims to measure skeletal muscle metabolism in vivo during exercise using the non-invasive Magnetic Resonance Spectroscopy (MRS) technique. Specifically, phosphocreatine (PCr) kinetic and Acetylcarnitine levels will be determined at resting, during exercise and during the recovery post exercise. The target population is adult healthy men, with a wide range of maximal physical capacity.

Clinical Trial Description

Skeletal muscle mitochondrial activation during the transition from resting metabolism to exercise may modulated by CrAT activity. Furthermore, dynamic changes in acetylcarnitine during the transition from exercise to resting metabolism (acetylcarnitine off-kinetic) may also reflect the action of CrAT protein. To date, the only possibility to get information on CrAT activity is by taking a muscle biopsy and perform enzyme activity assays ex vivo. By dynamic MRS scanning, it might be possible to deduce information that reflects CrAT activity, thereby making the biopsy sampling unnecessary. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03697928
Study type Observational
Source Maastricht University
Contact
Status Completed
Phase
Start date March 12, 2019
Completion date February 1, 2020
View Details
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