Clinical Trials Logo

Clinical Trial Summary

Diets containing fruit rich in anthocyanins have been shown (in meta-analyses) to be beneficial for health, but intervention trials have shown inconsistent results. In this preliminary study we want to investigate the influence of a tart-cherry juice intervention on vascular function and explore metabolite profiles that may offer insight into their mechanism of action


Clinical Trial Description

Cardiovascular disease (CVD) is the primary cause of morbidity and mortality. Tart cherries (TC) can positively impact major risk factors of CVD, activities thought to be related to their phytochemical content. However, data from human trials is less clear. TC have been shown to reduce systolic blood pressure (SBP) after acute, short-term and chronic intake, and to improve vascular dysfunction, presumably due to their antioxidant and anti-inflammatory activities. Other studies have not shown benefits of TC on SBP or vascular function and studies are difficult to interpret with different populations, dosing and durations being used as well as a lack of understanding for any underlying mechanisms. To account for the latter, the use of metabolomics has become increasingly popular in nutritional research. Therefore, the aim of this preliminary study was to characterise the effects of TC supplementation on vascular function with a 4-week intervention and explore if metabolomics can provide mechanistic evidence and this will inform for future chronic studies with TC juice. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04840160
Study type Interventional
Source Northumbria University
Contact
Status Completed
Phase N/A
Start date April 1, 2016
Completion date August 1, 2019

See also
  Status Clinical Trial Phase
Recruiting NCT04528004 - Mechanistic Studies of Nicotinamide Riboside in Human Heart Failure Early Phase 1
Completed NCT04597983 - Effect of 8-week Intake of 2S-hesperidin on Performance, Body Composition and Biochemicals Markers in Amateur Cyclists N/A
Completed NCT03445234 - Blueberries, Bananas, Exercise Recovery N/A
Recruiting NCT04892199 - Does GLP-1RA Prevent Deterioration of Metabolic State in Prediabetic and Diabetic Patients Treated With Antipsychotic Medication? Phase 4
Active, not recruiting NCT05070585 - Isothiocyanates and Metabolic Health Phase 1/Phase 2
Not yet recruiting NCT05494151 - Metabolic Substrate of Patients With Myocardial Infarction With and Without Modifiable Cardiovascular Risk Factors
Completed NCT04787952 - Insight Into New Brown Adipose Tissue Activators.
Completed NCT05758857 - Multiple Risk Factor Intervention Trial N/A
Completed NCT02689882 - "Pharmacokinetic Study of Nicotinamide Riboside" Phase 1
Completed NCT01674426 - Pathogenesis of Functional Hypothalamic Amenorrhea N/A
Recruiting NCT06252922 - Diet-Induced Changes in GEnetic Material
Completed NCT06326840 - Clinical Efficacy and Adverse Reactions of Antipsychotic Treatment N/A
Completed NCT04009642 - Cardiac Rest and Stress Metabolism in Patients With Type 2 Diabetes
Withdrawn NCT03515642 - Exercise, Gut Microbiota in Sedentary Adults With Overweight N/A
Not yet recruiting NCT05773183 - Exploring the Relationship Between Androgen Metabolism, Metabolic Disease and Skeletal Muscle Energy Balance in Men
Completed NCT04266665 - Effect of Dexmedetomidine on Brain Homeostasis and Neurocognitive Outcome Phase 4
Completed NCT03697928 - Markers of Carnitine Acetyltransferase (CrAT) Protein Activity and Carnitine Availability
Recruiting NCT04469790 - Effects of Multi-day Interruptions in Sitting on Type 2 Diabetes-relevant Outcomes in Children N/A
Completed NCT03573999 - Effect of Mannitol 20% Versus Hypertonic Saline 7.5% in Brain Metabolism and Oxygenation Phase 4
Active, not recruiting NCT05977569 - Physiological and Sensory Responses to Prolonged Fasting in Humans N/A