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NCT01935791 Clinical Trial

Investigating Brown Adipose Tissue Activation in Humans

Metabolic Diseases Clinical Trial

Official title:
Investigating Brown Adipose Tissue Activation in Humans

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT01935791
Other study ID # 13HH0688
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date July 2013
Est. completion date November 5, 2018

Study information
Verified date May 2021
Source Imperial College London
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The purpose of this study is to determine what can activate brown adipose tissue (BAT).

Description:

We will investigate different stimuli (i.e. hormones) to determine which can stimulate BAT.

Recruitment information / eligibility
Status Completed
Enrollment 11
Est. completion date November 5, 2018
Est. primary completion date November 5, 2018
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - aged >18 years Exclusion Criteria: - medical conditions - recreational drug use - participation in other trials within the preceding 2 months - blood donation within 3 months of study participation

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• Period 1 Visit 1 - Cold PET-CT Vehicle, Visit 2 -Warm PET-CT Vehicle
Temperature
Drug:
• Period 1 Visit 1 - Cold PET-CT Vehicle, Visit 2 -Warm PET-CT Glucagon
Hormone
Other:
• Period 1 Visit 1 - Cold PET-CT Vehicle, no visit 2 as BAT negative
Temperature
Drug:
• Period 2 - Visit 1 Warm Control vehicle, Visit 2 Warm Glucagon, Visit 3 Cold control
Hormone
• Period 2 - Visit 1 Warm Glucagon, Visit 2 Cold control , Visit 3 Warm control
Hormone
• Period 2 -Visit 1 cold control, Visit 2 warm control, Visit 3 Warm glucagon
hormone
• Period 2 -Visit 1 cold control, visit 2 warm glucagon, visit 3 warm control
hormone
• Period 2- Visit 1 Warm glucagon, visit 2 warm control, visit 3 cold control
hormone
• Period 2 - Visit 1 Warm control, visit 2 cold control, visit 3 warm glucagon
Hormone

Locations
Country Name City State
United Kingdom Imperial College London London

Sponsors (1)
Lead Sponsor Collaborator
Imperial College London

Country where clinical trial is conducted

United Kingdom, 

References & Publications (1)

Salem V, Izzi-Engbeaya C, Coello C, Thomas DB, Chambers ES, Comninos AN, Buckley A, Win Z, Al-Nahhas A, Rabiner EA, Gunn RN, Budge H, Symonds ME, Bloom SR, Tan TM, Dhillo WS. Glucagon increases energy expenditure independently of brown adipose tissue acti — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary Brown Adipose Tissue Activation Following Glucagon or Saline Infusion Period 1 Brown Adipose Tissue (BAT) activation measured using metabolic rate of glucose (MR[gluc]) during F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET-CT) for Cold PET-CT Vehicle vs Warm PET-CT Vehicle vs warm PET-CT Glucagon. 2hours
Primary Increase in Energy Expenditure Following Glucagon or Saline Infusion Period 2 Increase in energy expenditure measured using indirect calorimetry for Cold control vs Warm Control vs Warm Glucagon. 2hours
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