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Metabolic Acidosis clinical trials

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NCT ID: NCT06327737 Completed - Metabolic Acidosis Clinical Trials

Diabetic Ketoacidosis Diagnosis and Management

Start date: December 15, 2020
Phase:
Study type: Observational [Patient Registry]

This is the first and only study conducted on the use of capnography in children diagnosed with DKA to evaluate the initial clinical grading of DKA, monitor clinical improvement, and predict complications such as brain edema.

NCT ID: NCT05970094 Completed - Kidney Diseases Clinical Trials

Reduction of Metabolic Acidosis in Patients With Chronic Kidney Disease in Stage 4 and 5

REMA-CKD
Start date: March 6, 2023
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to learn about and test the effect of an acid/base diet, in chronic kidney patients with CKD stage 4 and 5 in an interventional study with a historical control. The hypothesize is, that an acid/base diet will reduce the degree of acidosis and the need for oral bicarbonate supplements.

NCT ID: NCT05940935 Completed - Metabolic Acidosis Clinical Trials

The Relationship of Developing Metabolic Acidosis With Antiepleptic Drugs in Craniotomy Operations

Start date: May 22, 2023
Phase:
Study type: Observational

The relationship of developing metabolic acidosis with antiepleptic drugs in craniotomy operations

NCT ID: NCT05147051 Completed - Metabolic Acidosis Clinical Trials

Meglimine Sodium Succinate for Correction of Metabolic Acidosis in Critically Ill Patients

Start date: June 16, 2021
Phase: Phase 2
Study type: Interventional

An acid-base imbalance, called metabolic acidosis (acid-base disorder lasting from several minutes to several days, caused by a decrease in serum bicarbonate ion (HCO3) concentration), is often observed in critically ill patients with various underlying diseases. Metabolic acidosis has a negative impact on the cardiovascular, respiratory, digestive, nervous, excretory, hematological, endocrine, musculoskeletal and immune systems and is associated with unfavourable outcomes. Reamberin® is a solution of disubstituted sodium salt of succinic acid, which has an alkaline reaction and succinate is capable to integrate into the Krebs cycle and restore energy metabolism in the cell. The aim of the present study is to evaluate the efficacy and safety of meglumine sodium succinate at a dose of 500 to 3000 ml in critically ill patients with metabolic acidosis and choose the optimal volume of its solution for the correction of metabolic acidosis in critically ill patients.

NCT ID: NCT04975906 Completed - Critical Illness Clinical Trials

The Threshold of Serum Anion Gap as a Screening Tool for Organic Acidosis

Start date: July 1, 2017
Phase:
Study type: Observational

Background: The serum anion gap (AG) is commonly used as a screening tool for acid-base disorders. With modern laboratory techniques using ion-selective electrodes to measure the main electrolyte components of the AG, our definition high AG (HAGMA) should be reviewed. Aim: This study aims to assess the diagnostic value of AG and to determine a diagnostic threshold for HAGMA in a high-prevalence clinical setting. Method: Computerized extraction of anonymised data from electronic medical records was performed. A pre-defined criteria included all inpatients of an acute-care hospital who had measurements for organic acids (lactate, ketone or salicylate) paired with a serum urea, electrolyte and creatinine panel.

NCT ID: NCT04600323 Completed - Clinical trials for Chronic Kidney Disease

Bicarbonate Administration and Cognitive Function in Midlife and Older Adults With CKD

Start date: February 1, 2021
Phase: Early Phase 1
Study type: Interventional

This is a pilot, randomized, double-blinded, placebo-controlled, 12-month trial of 50 patients with CKD stage 3b-4 with metabolic acidosis to examine the effect of sodium bicarbonate therapy on cognitive and cerebrovascular function.

NCT ID: NCT04229069 Completed - Metabolic Acidosis Clinical Trials

Acid-Base Balance, Metabolism and Minerals

BASICA
Start date: January 3, 2013
Phase: N/A
Study type: Interventional

Metabolism is controlled by macro- and micronutrients. Protein-rich diets should lead to latent acidosis at tissue level with further negative implications. Food supplements with alkaline salts are available and popular pretending to prevent these changes. Within a randomized double-blind placebo-controlled trial, the investigators tested the hypotheses 1) that a 4-week protein-rich diet induces a latent tissue acidosis and 2) an alkaline supplement can compensate this. Acid-base balance and important metabolic parameters were determined before and after 4 weeks of supplementation by peripheral blood samples, indirect calorimetry and muscle microdialysis before and after a protein-rich test meal.

NCT ID: NCT03428464 Completed - Clinical trials for Kidney Transplant; Complications

Bicarbonate Administration in Kidney Transplant Recipients

Start date: December 5, 2018
Phase: N/A
Study type: Interventional

Metabolic acidosis is associated with vascular endothelial dysfunction and is a common complication in patients who have received a kidney transplant. Kidney transplant recipients (KTR) with lower serum bicarbonate levels, even within the normal range, have an increased risk of graft loss and mortality. The investigators propose a prospective, double-blind, randomized, placebo-controlled, 18-week crossover pilot study to examine the effects of sodium bicarbonate on vascular endothelial function, graft function, and cognitive function in 20 KTR patients.

NCT ID: NCT03390842 Completed - Metabolic Acidosis Clinical Trials

Long-term Safety Extension to Study TRCA-301

Start date: December 20, 2017
Phase: Phase 3
Study type: Interventional

This study is a 40-week, blinded, placebo-controlled extension of Study TRCA-301 (NCT03317444). Eligible subjects who complete the 12-week treatment period in Study TRCA-301 have the option to participate in this extension study evaluating the long-term safety and durability of effect of TRC101 in subjects with non-dialysis dependent chronic kidney disease and metabolic acidosis. Eligible subjects will be treated with TRC101 or placebo once daily (QD) on an out-patient basis for the subsequent 40 weeks. Subjects will continue to receive the same blinded treatment (TRC101 or placebo) that they received in Study TRCA-301.

NCT ID: NCT03317444 Completed - Metabolic Acidosis Clinical Trials

Evaluation of TRC101 in Subjects With Metabolic Acidosis Associated With Chronic Kidney Disease

Start date: September 26, 2017
Phase: Phase 3
Study type: Interventional

This is a multicenter, double-blind, placebo-controlled, parallel-design study. The study will enroll approximately 210 adult male and female subjects with stage 3 or 4 chronic kidney disease and metabolic acidosis. The study dosing (TRC101 or placebo) will continue for 12 weeks once daily. The maximum study duration is anticipated to be up to 16 weeks.