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Neoadjuvant Nivolumab and Relatlimab in Merkel Cell Carcinoma

Merkel Cell Carcinoma Clinical Trial

Official title:
A Phase 2, Open Label, Single Arm Clinical Trial of Neoadjuvant Nivolumab and Relatlimab in Stage I To III Resectable Merkel Cell Carcinoma

Clinical Trial Summary

The goal of this clinical trial is to test neoadjuvant dual immunotherapy in Merkel cell carcinoma with the aim to improve recurrence-free survival

Clinical Trial Description

This is a phase 2, open label, single cohort, single centre, clinical trial of neoadjuvant immunotherapy with dual inhibition of PD-1 and LAG-3 immune checkpoint pathways. The hypothesis is that neoadjuvant therapy produces a higher pathological response rate (pCR) and a longer recurrence-free survival in a cohort of treatment-naïve patients with resectable stage I (≥10 mm) to stage III Merkel cell carcinoma compared to neoadjuvant nivolumab monotherapy in Checkmate 358 (n=123, NCT02488759, historical control). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06151236
Study type Interventional
Source Melanoma Institute Australia
Contact Monica Osorio
Phone + 61 2 9911 7296
Email monica.osorio@melanoma.org.au
Status Recruiting
Phase Phase 2
Start date March 11, 2024
Completion date April 2034
View Details
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