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Palliative RT & Anti-PD-1/PD-L1 Checkpoint Blockade in Metastatic Merkel Cell Carcinoma

Merkel Cell Carcinoma Clinical Trial

Official title:
A Phase 2 Study of Palliative Radiation Therapy and Anti-PD-1/PD-L1 Checkpoint Blockade in Patients With Metastatic Merkel Cell Carcinoma

Clinical Trial Summary

The primary objectives of this study are to assess 1) the safety and 2) efficacy of combining Anti-PD-1/PD-L1 blockade with palliative radiation therapy in patients with Stage IV Merkel Cell Carcinoma.

Clinical Trial Description

The hypothesis for this study is that local radiation therapy (RT) can be safely used in combination with PD-1/PD-L1 blockade. This combination therapy may have the potential to enhance the induction of systemic anti-Merkel cell carcinoma immune responses, which will inhibit growth and kill Merkel cell tumor cells in sites of established metastases outside of the local radiation therapy field. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03988647
Study type Interventional
Source Stanford University
Contact
Status Terminated
Phase Phase 2
Start date July 24, 2019
Completion date January 20, 2021
View Details
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