Mental Stress Clinical Trial
Official title:
Effect of Mental Stress on Platelet Function in Healthy Subjects
The aim of the project is to study the acute and chronic effect of mental stress on platelet adhesion and aggregation in two population composed of normal subjects at different ages
Psychological stress is an important cardiovascular risk factor. Activation of platelets
plays an important role in atherosclerosis development and it could be one of the mechanisms
linking psychological stress and cardiovascular diseases.
We plan to include 32 healthy subjects. (16 in every group). One group with subjects at age
20 - 49 and the other group with subjects at age 50 - 70 years.
The aim of the study will be to assess the acute and chronic effect of a standard short
mental stress (2-minute Bondet Test) on platelet function and of the level of endothelin-1,
catecholamines and cortisol. We plan to evaluate if age may play a role in the effect of
psychological stress on platelet function.
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Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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