Mental Retardation Clinical Trial
— REMOBOfficial title:
Phenotypic Characterization and Array CGH Analysis in Patients With Syndromic Obesity of Unknown Etiology
Comparative genomic hybridization (CGH) array technology has been used in numerous studies on mental retardation, and few chromosomal abnormalities have been identified in patients. Because chromosomal abnormalities have still been associated with obesity, we can expect that syndromic obesity is also associated with small deletions/duplications. Characterization of deleted or duplicated loci in these obese patients would mean that these loci include genes implicated in obesity. This will permit to propose new gene(s) involved in obesity. (In french: Caractérisation phénotypique et recherche de REManiements chromosomiques chez des patients présentant une OBésité syndromique de cause non identifiée : REMOB)
Status | Completed |
Enrollment | 90 |
Est. completion date | January 2011 |
Est. primary completion date | January 2011 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | N/A to 18 Years |
Eligibility |
Inclusion Criteria: - children (under 18 year-old) - obesity (following IOTF definition) - at least one criteria among : - mental retardation - facial dysmorphism - at least one major malformation (uro-genital, cardiac, skeletal, cerebral, ophthalmologic…) Exclusion Criteria: - common obesity - obesity with an identified aetiology |
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Country | Name | City | State |
---|---|---|---|
France | Service de Génétique de médicale - Hopital des enfants - Pellegrin | Bordeaux | |
France | Centre de Génétique Hôpital d'Enfants CHU de Dijon | Dijon | |
France | Génétique Médicale HOPITAL DEBROUSSE HCL | Lyon | |
France | Département de Génétique Médicale Centre de référence anomalies du développement Centre de compétence maladies osseuses constitutionnelles Hôpital Arnaud de Villeneuve CHRU Montpellier | Montpellier | |
France | Département de Génétique Hôpital Robert DEBRE Centre de Référence Maladies Rares "Anomalies du Développement & Syndromes Malformatifs" | Paris | |
France | Hopital des Enfants, CHU de Toulouse | Toulouse |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Bordeaux |
France,
Cole TJ, Bellizzi MC, Flegal KM, Dietz WH. Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ. 2000 May 6;320(7244):1240-3. — View Citation
Delrue MA, Michaud JL. Fat chance: genetic syndromes with obesity. Clin Genet. 2004 Aug;66(2):83-93. Review. — View Citation
Fan YS, Jayakar P, Zhu H, Barbouth D, Sacharow S, Morales A, Carver V, Benke P, Mundy P, Elsas LJ. Detection of pathogenic gene copy number variations in patients with mental retardation by genomewide oligonucleotide array comparative genomic hybridization. Hum Mutat. 2007 Nov;28(11):1124-32. — View Citation
Ichihara S, Yamada Y. Genetic factors for human obesity. Cell Mol Life Sci. 2008 Apr;65(7-8):1086-98. Review. — View Citation
Rosenberg C, Knijnenburg J, Bakker E, Vianna-Morgante AM, Sloos W, Otto PA, Kriek M, Hansson K, Krepischi-Santos AC, Fiegler H, Carter NP, Bijlsma EK, van Haeringen A, Szuhai K, Tanke HJ. Array-CGH detection of micro rearrangements in mentally retarded individuals: clinical significance of imbalances present both in affected children and normal parents. J Med Genet. 2006 Feb;43(2):180-6. Epub 2005 Jun 24. — View Citation
Schoumans J, Ruivenkamp C, Holmberg E, Kyllerman M, Anderlid BM, Nordenskjöld M. Detection of chromosomal imbalances in children with idiopathic mental retardation by array based comparative genomic hybridisation (array-CGH). J Med Genet. 2005 Sep;42(9):699-705. — View Citation
Stankiewicz P, Beaudet AL. Use of array CGH in the evaluation of dysmorphology, malformations, developmental delay, and idiopathic mental retardation. Curr Opin Genet Dev. 2007 Jun;17(3):182-92. Epub 2007 Apr 30. Review. — View Citation
Zung A, Rienstein S, Rosensaft J, Aviram-Goldring A, Zadik Z. Proximal 19q trisomy: a new syndrome of morbid obesity and mental retardation. Horm Res. 2007;67(3):105-10. Epub 2006 Oct 19. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Evaluation of the prevalence of cryptic chromosomal imbalance in patients with syndromic obesity of unknown etiology. | 3 - 6 months | No | |
Secondary | prevalence of the main genetic aetiologies of syndromic obesity | 3 - 6 months | No | |
Secondary | Characterization of the main features evocative of subcryptic chromosomal anomalies in this population | 3 - 6 months | No | |
Secondary | Phenotypic description of some "new" syndromes with obesity | 3 - 6 months | No | |
Secondary | candidate genes implicated in the development of obesity. | 3 - 6 months | No | |
Secondary | Delineation of an aetiological screening protocol in patients with syndromic obesity | 3 - 6 months | No |
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