Adaptive Treatment for Adolescent Cannabis Use Disorders

Mental Disorders Clinical Trial

Official title:

Adaptive Treatment for Adolescent Cannabis Use Disorders

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01656707
• Other study ID #: PA08-263
• Secondary ID: R01DA030454
• Status: Completed
• Phase: N/A
• First received: August 1, 2012
• Last updated: April 10, 2017
• Start date: September 2011
• Est. completion date: July 2016

Study information

• Verified date: April 2017
• Source: UConn Health
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to examine an Adaptive Treatment approach in order to improve outcomes of youth with Cannabis Use Disorders who are poor responders to treatment.

Description:

The study will address the current contrasts in youth response to treatment, the problem of poor response to treatment and the prevention of relapse. Results from the study may support Adaptive Treatment as an efficacious approach for youth with Cannabis Use Disorder who are poor responders to treatment.

Poor responders fall into two categories, those who failed to achieve a negative drug urinalysis during the last session of the initial MET/CBT-7 treatment they attended, and those who either dropped out or were administratively discharged at any time during the initial MET/CBT-7 treatment.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 172
• Est. completion date: July 2016
• Est. primary completion date: July 2016
• Accepts healthy volunteers: No
• Gender: All
• Age group: 13 Years to 18 Years

Eligibility

Inclusion Criteria:

• 13-18 years of age at the time of intake assessment

• Current diagnosis of DSM-IV Cannabis Abuse or Dependence

• Able to read and comprehend English at a 5th grade level

• Residence within 45 minutes drive from the UCHC Farmington treatment site

• Participant and a parent/legal guardian responsible for providing collateral information agree to sign an IRB approved consent form

• Participant and a parent/legal guardian responsible for providing collateral information agree to provide locator information

• The family is not planning to move from the area during the next six months

Exclusion Criteria:

• Meet criteria for dependence of any other substance of abuse other than nicotine or alcohol

• Report suicidal ideation with a plan, suicidal behavior, a plan to hurt oneself or other, or a history of self-injurious behavior all occurring in the last 30 days

• Meet a lifetime diagnosis of schizophrenia

• Has any current health (i.e. medical, psychiatric) condition that will compromise the participant's ability to regularly attend treatment

• Demonstrate an inability or unwillingness to provide locator information

Related Conditions & MeSH terms

• Addictive Behaviors
• Behavior, Addictive
• Cannabis Use Disorder
• Disease
• Marijuana Abuse
• Mental Disorders
• Psychotic Disorders

Intervention

Behavioral:
• ACRA
Ten weekly,60-minute therapy sessions including six individual, two parent/guardian and two joint (individual and parent/guardian).
• CBT
10 weekly, 60-minute sessions of augmented individualized CBT

Locations

Country	Name	City	State
United States	University of Connecticut Health Center	Farmington	Connecticut

Sponsors (2)

Lead Sponsor	Collaborator
UConn Health	National Institute on Drug Abuse (NIDA)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	1.) To evaluate the efficacy of AT for youth who have been defined as poor responders to an evidence-based practice intervention such as the initial MET/CBT-7.	Each participant will serve as his/her own control. The outcomes will include the T-ASI, T-ASI-P, and drug urinalyses.	one year
Secondary	To assess outcomes as a function of mediator variables such as self-efficacy, coping skills, readiness to change, and environmental support (i.e., family and peer), within each of the AT interventions.	The secondary outcome measures will include the SCQ, CRI, PRQ, and SSQ.	one year