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Menopause, Premature clinical trials

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NCT ID: NCT04189406 Recruiting - Infertility, Female Clinical Trials

Turner Syndrome Minipuberty Study

Minipuberty
Start date: February 1, 2020
Phase:
Study type: Observational

Rationale: Due to accelerated germ cell loss, infertility is a major problem in girls with Turner syndrome (TS). Therefore, cryopreservation of ovarian tissue or oocytes before exhaustion of the ovarian reserve may preserve fertility in patients with TS. However, in the majority of females with TS , the ovarian reserve is exhausted before the age of menarche. Early markers indicating and predicting the ovarian reserve are necessary. During mid-childhood the hypothalamic-pituitary-gonadal (HPG) axis is quiescent and gonadotropins are usually unmeasurable. Nonetheless, this axis is active during infancy. Therefore, gonadotropins are measurable with peak values at 3 months of age and with lower (but still measurable) values at 9 months of age, in a period called the minipuberty. The aim of this study is to find markers of ovarian capacity, during the minipuberty, in order to predict ovarian reserve in the future. Objective: The hormonal range of LH, FSH, AMH, inhibin B, testosterone and estradiol in girls with TS during the minipuberty and the relation of the hormone serum levels with the karyotype. Study design: A prospective, cohort study with a duration of 3 years. Study population: Girls with a pre- or perinatal diagnosis TS who are born in a medical centre in the Netherlands during the duration of the study Main study parameters/endpoints: Serum levels of FSH, LH, AMH, inhibin B, testosterone and estradiol at the age of 3 and 9 months.

NCT ID: NCT04167033 Recruiting - Clinical trials for Premature Ovarian Insufficiency

Ventricular Repolarization in Patients With Premature Ovarian Insufficiency (QT-IOP)

QT-IOP
Start date: April 14, 2021
Phase: N/A
Study type: Interventional

Ventricular repolarization, measured by corrected QT interval (QTc), is influenced by sex hormones. A QTc above 460msec predisposes to the risk of "torsades-de-pointes"(TdP). The investigators have recently shown that estradiol determines an increase in QTc elongation and progesterone shortens it. In addition, high gonadotropin levels (FSH or LH) are associated with QTc prolongation. Hypergonadotropic hypogonadisms (low progesterone and high gonadotropins) are therefore hormonal situations that promote QTc prolongation. Premature ovarian insufficiency (POI) is one of them. Its management is based on the prescription of hormone replacement therapy (HRT). Epidemiological studies have shown that these patients would be at increased risk of cardiovascular mortality. Our team is interested in the effect of this pathological hormonal situation and its HRT on ventricular repolarization in order to define whether this is a population at risk for long QTc.

NCT ID: NCT04082169 Recruiting - Clinical trials for Primary Ovarian Insufficiency

Causes and Consequences of Primary Ovarian Insufficiency

Clinical POI
Start date: January 11, 2019
Phase:
Study type: Observational

100 women with primary ovarian insufficiency will be included for extensive diagnostic workup to improve diagnostic precision by extended autoantibody screening and genetic and toxicological testing.

NCT ID: NCT04031456 Recruiting - Clinical trials for Premature Ovarian Failure

Autologous PRP Infusion May Restore Ovarian Function and May Promote Folliculogenesis in POI Patients

PRP
Start date: July 30, 2019
Phase: Phase 2/Phase 3
Study type: Interventional

Autologous PRP intra ovarian infusion may restore ovarian function, may promote folliculogenesis and may improve patients' hormonal profile in patients presenting with POI.

NCT ID: NCT03861715 Recruiting - Infertility Clinical Trials

Single Follicular Dexarelix for LH Suppression During Ovarian Stimulation in Oocyte Donors.

Start date: January 2017
Phase:
Study type: Observational

A randomized prospective study in the evaluation of the long acting GnRH antagonist Degarelix against the classical multidose regime with Ganirelix for LH suppression during the follicular phase of an ovarian stimulation cycle in oocyte donors.

NCT ID: NCT03518944 Recruiting - Clinical trials for Primary Ovarian Insufficiency

Establishing of an Early Warming System of Premature Ovarian Insufficiency

Start date: July 1, 2017
Phase:
Study type: Observational [Patient Registry]

Premature ovarian insufficiency (POI) is a clinical syndrome defined by loss of ovarian activity before the age of 40 years. The POI guideline development group of ESHRE recommends the following diagnostic criteria: oligo/ amenorrhea for at least 4 months and an elevated follicle stimulating hormone (FSH) level >25 mIU/mL on two occasion >4 weeks apart. Some clinicians and researchers proposed that POI was a progressive disease and there were three stages of POI: occult POI, biochemical POI, overt POI. However, there is lack of reliable indicators to assess the different stages of POI. The present study is to explore the change of menstruation condition, basal follicle-stimulating hormone, anti-müllerian hormone and antral follicle count during the development of POI, and whether those marks can assess the different stages of POI.

NCT ID: NCT03518918 Recruiting - Clinical trials for Primary Ovarian Insufficiency

Establishing the Diagnosis Standard and Analysis the Risk Factors of POI in Chinese Women

Start date: September 1, 2016
Phase:
Study type: Observational

The study aims to establishing the diagnosis standard of POI and analyzing the risk factors in Chinese women.

NCT ID: NCT03496636 Recruiting - Female Infertility Clinical Trials

Autologous Ovarian Tissue Transplantation

Start date: March 1, 2021
Phase: N/A
Study type: Interventional

Chemotherapy and radiation for cancer and other conditions can cause infertility. Several centers around the world are cryopreserving ovarian tissue from these patients though an experimental protocol, including the Fertility Preservation Program in Pittsburgh (protocol PRO08050491). The objective of this study is to study the efficacy and safety of autologous tissue transplantation in patients diagnosed with primary ovarian insufficiency after chemotherapy and/or radiation treatments.

NCT ID: NCT03480412 Recruiting - Infertility, Female Clinical Trials

Second Step Protocol in Poor Ovarian Responder (POR)

POR
Start date: September 1, 2017
Phase:
Study type: Observational

Reduced ovarian reserve and the consequent poor ovarian response are very recurent in infertile patients, indeed a percentage of 10%-24% of couples addressed to infertility program may be classified as Poor Ovarian Responder (POR). Objective: To evaluate whether the repeated luteal phase stimulation (Second Step) permits a significantly higher number of oocytes retrieved in POR when compared to conventional follicular stimulation. Interventions: The follicular phase stimulation is conduced according to a standardized Antagonist protocol or Short protocol (with GnRH agonist) using recombinant or urinary gonadotropins (starting dose 300 or 450 UI) or a long lasting recombinant gonadotropin (Corifollitropin alfa 150 mcg). Two - six days after the first oocyte retrieval a second gonadotropin stimulation will be started with a GnRH antagonist protocol (the stimulation will be started with 250 UI of human menopausal gonadotropin (hMG) and a GnRH antagonist (GnRH-an) 0,25 mg\die will be administered when the leading follicle is ≥ 14 mm until hCG (human chorionic gonadotropin) criteria are met. When at least two follicles had reached 17-18 mm in diameter, ovulation will be triggered with a single subcutaneous bolus of urinary human chorionic gonadotropin (10.000 UI ) and oocyte retrieval will be performed after 35 hours. Two or Three months after the second oocyte retrieval the Embryo transfer (ET) will be performed after endometrial preparation with Estradiol Valerate and intramuscular Progesterone.

NCT ID: NCT03474120 Recruiting - Clinical trials for Premature Ovarian Failure

Prospective Genetic Study in Patients With Ovarian Insufficiency

Start date: April 20, 2018
Phase:
Study type: Observational

genetic screening and etiological analysis was conducted on patients with ovarian insufficiency and decline in ovarian reserve. All patients were enrolled in the IVF-treated and non-IVF-treated groups, followed up for long-term treatment outcomes and genomic screening.