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Meniscus Tear clinical trials

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NCT ID: NCT04753424 Recruiting - Clinical trials for Patient Satisfaction

Semitendinosus Graft as Meniscal Transplant

Start date: January 1, 2018
Phase:
Study type: Observational

Removal of meniscal tissue is described to result in poor knee function and a significant risk for future development of osteoarthritis. Different implants have been suggested to substitute a removed meniscus. Meniscal allograft transplantation is not widely available due to costs and availability. The semitendinosus tendon is a known graft with biological properties with potential to remodel and revascularize in an intraarticular environment such as anterior cruciate ligament reconstruction. The objective for this study was to investigate whether the semitendinosus tendon graft could function as a meniscal transplant.

NCT ID: NCT04641351 Enrolling by invitation - Clinical trials for Osteoarthritis, Knee

Corticosteroid Meniscectomy Randomized Trial

CoMeT
Start date: May 27, 2021
Phase: Phase 4
Study type: Interventional

Synovitis has an important role in the symptoms and progression of Osteoarthritis (OA). Inflamed synovium has been associated with both increased symptoms and increased progression in OA patients. Furthermore, synovitis observed during knee arthroscopy in our patients undergoing arthroscopic partial meniscectomy (APM) was associated with worse symptoms while adjusting for confounding factors.Therefore, a better understanding of synovitis as a predictor of outcome after APM and as a target for treatment is needed to improve outcomes in this patient population. Triamcinolone has been shown to decrease synovitis-associated outcomes in both animal and human studies after anterior cruciate ligament (ACL) injury. In a porcine model of ACL injury, treatment with triamcinolone resulted in decreased formation of synovitis-related collagen breakdown products as well as decreased cellularity of the synovium.And in a trial of triamcinolone injected after ACL injury, similar findings of decreased C-telopeptide of type II collagen (CTX-II), associated with collagen type II breakdown, was found in knees administered triamcinolone compared to placebo controls.

NCT ID: NCT04572256 Recruiting - ACL Injury Clinical Trials

MOntelukast as a Potential CHondroprotective Treatment Following Anterior Cruciate Ligament Reconstruction (MOCHA Trial)

MOCHA
Start date: February 1, 2021
Phase: Early Phase 1
Study type: Interventional

This is a multicenter randomized, placebo-controlled trial to assess whether a 6-month course of oral montelukast after ACL reconstruction reduces systemic markers of inflammation and biochemical and imaging biomarkers of cartilage degradation. This study will specifically target older ACL reconstruction patients with concomitant meniscal injuries as this group is at greatest risk of rapid PTOA progression. Patients will randomly be assigned to receive oral montelukast (10 mg) versus placebo daily for 6 months after surgery.

NCT ID: NCT04361487 Active, not recruiting - Meniscus Tear Clinical Trials

Circumferential Compression STITCH Repairs of Complex and Horizontal Cleavage Meniscal Tears

NOVOSTITCH PRO
Start date: November 13, 2020
Phase:
Study type: Observational

The purpose of this study is to understand the benefits and safety of the NOVOSTITCH PRO Meniscal Repair (NOVOSTITCH PRO) system. The meniscus is a tissue in the knee joint. The NOVOSTITCH PRO is used during surgery to fix meniscus tears in the knee. It is unknown whether fixing a meniscus tear is better than the approach of removing the tear. Data will be collected on participants prior to surgery, at surgery, and for 2 years after surgery.

NCT ID: NCT03037242 Enrolling by invitation - Meniscus Tear Clinical Trials

Outcomes of Meniscus Root Repair Using a Transtibial Pullout Technique

Start date: May 1, 2017
Phase: N/A
Study type: Interventional

The results of this study will optimize the care for patients with a meniscus root tear. Surgeons will be able to determine if MRR (meniscus root repair) with transtibial pullout technique is an effective treatment and will identify potential risk factors for poor clinical outcomes. In addition, investigators will determine if MRR is successful in delaying the radiographic progression of arthritis in the involved compartment.

NCT ID: NCT02237001 Completed - Meniscus Tear Clinical Trials

Study of Suture Repair of Torn Meniscus in the Knee

STITCH
Start date: November 19, 2014
Phase: N/A
Study type: Interventional

Horizontal meniscus tears meeting specified criteria will be repaired by any commonly used suture technique. Subjects will be followed for 2 years to evaluate the effectiveness of the repair, by assessing the re-operation rate, and by assessing improvements in knee pain and knee function.

NCT ID: NCT02100059 Completed - Meniscus Tear Clinical Trials

Motor and Sensory Deficits Following Partial Meniscectomy

Start date: October 2013
Phase: N/A
Study type: Interventional

To determine changes in thigh muscle function and knee pain after a partial meniscectomy surgery and to also determine the effects of applying electrical stimulation to the knee to determine if this improves thigh muscle function and decreases pain.

NCT ID: NCT02025400 Completed - Knee Injuries Clinical Trials

Internet Enhanced, Patient-Centered Orthopedic Care: A Prospective, Randomized, Controlled Pilot Trial

Start date: July 2012
Phase: Phase 1
Study type: Interventional

The investigators have previously reported on patient utilization of an eRehab patient education web portal that utilizes streaming, clinician prescribed video instruction to motivate and inform patients in self-care of their orthopedic condition, focusing on the importance of a home exercise program. The greatest barrier to patient use of this web-based home exercise treatment plan was the initial access to the program. The purpose of this study is to compare an Internet-based patient education rehab portal (eRehab) to formal physical therapy (PT) in terms of patient costs and outcomes.

NCT ID: NCT01931735 Completed - Meniscus Tear Clinical Trials

Prospective Trial of Arthroscopic Meniscectomy for Degenerative Meniscus Tears

Start date: October 1, 2013
Phase: N/A
Study type: Interventional

Arthroscopic meniscectomy is among the most commonly performed orthopedic surgical procedures in the VA system. There remains substantial uncertainty, however, regarding the short term benefits and the long term consequences of arthroscopic meniscectomy in patients with degenerative meniscus tears. Of major concern is the fact that degenerative meniscus tears are associated with osteoarthritis, and it is known that within two years of surgery, arthroscopic debridement for osteoarthritis is no better than placebo in relieving pain and restoring function. Longer term, meniscectomy has been shown to be associated with elevated risk of osteoarthritis development, raising the concern that meniscectomy can actually be harmful. The purpose of this study is to determine whether meniscectomy in the setting of a degenerative meniscus tear is of any clinical value. Determining this would either justify the expenses associated with arthroscopic meniscectomy on a large number of patients, or would identify an area of significant potential cost savings.

NCT ID: NCT01528228 Completed - Meniscus Tear Clinical Trials

Effects of TENS Therapy Following Arthroscopic Knee Surgery

TENS
Start date: July 1, 2011
Phase: N/A
Study type: Interventional

Following standard of care procedures for arthroscopy knee surgery it is anticipated that Transcutaneous Electrical Nerve Stimulation (TENS) will provide improved pain relief and improve functional outcomes.