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Meningitis, Cryptococcal clinical trials

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NCT ID: NCT04072640 Active, not recruiting - HIV/AIDS Clinical Trials

Three Induction Treatments on Cryptococcal Meningitis

TITOC
Start date: January 25, 2021
Phase: Early Phase 1
Study type: Interventional

Three induction treatment strategies [ voriconazole +5FC vs. amphotericin deoxycholate (0.4-0.5 mg/kg/d)+5FC vs. amphotericin deoxycholate (0.7-1.0 mg/kg/d)+5FC ] for HIV-infected patients with cryptococcal meningitis were compared.

NCT ID: NCT03267407 Active, not recruiting - HIV/AIDS Clinical Trials

Vietnam Cryptococcal Retention in Care Study - Version 2.1

Start date: August 14, 2015
Phase: N/A
Study type: Observational

This is a multicenter prospective cohort evaluation of the implementation of a cryptococcal antigen (CrAg) screening program at selected outpatient HIV clinics (OPCs) and network laboratories in Vietnam.

NCT ID: NCT02624453 Active, not recruiting - Clinical trials for Cryptococcal Meningitis

Pre-Antiretroviral Therapy (ART) Cryptococcal Antigen Screening in AIDS

PreCASA
Start date: July 2015
Phase: N/A
Study type: Interventional

The aim of the study is to evaluate systematic pre-antiretroviral cryptococcal antigen screening and pre-emptive fluconazole therapy in antigen positive patients, as a strategy to reduce morbidity and mortality due to AIDS associated cryptococcal meningitis in patients starting antiretroviral therapy at <100 CD4 in Cameroon.

NCT ID: NCT02334670 Active, not recruiting - Clinical trials for Meningitis, Cryptococcal

Vietnam Cryptococcal Retention in Care Study Version 1.0

CRICS
Start date: August 14, 2015
Phase: N/A
Study type: Observational

It is hypothesized that implementing plasma CrAg screening in clinics providing routine HIV care will enable identification of Vietnamese adult patients with advanced HIV (CD4 ≤100 cells/μL) who have early cryptococcal disease, enable prompt preemptive treatment with high-dose fluconazole, and improve survival.

NCT ID: NCT01715922 Active, not recruiting - HIV Clinical Trials

Study Evaluating Efficiency and Tolerance of High-dose Fluconazole Associated With Flucytosine as Induction Therapy for Cryptococcal Meningitis Associated With HIV in Sub-saharan Africa

Flucocrypto
Start date: May 2012
Phase: Phase 2/Phase 3
Study type: Interventional

The aim of the trial is to demonstrate that in a sub-Saharan African setting, the association of: 1. Oral treatment : high dose of fluconazole (1600mg/d) associated with flucytosine (100 mg/kg/j) as induction therapy 2. lumbar punctures to control intracranial pressure can decrease mortality rate below 35% at 10 weeks. This is a non-randomized open label pilot study, with standardized management of cryptococcoses meningitis and follow-up in Burundi and Ivory Coast. A total of 41 patients will be enrolled.