Systematic Search for Primary Immunodeficiency in Adults With Infections — SPIDAC  

Pneumococcal Infections Clinical Trial

Official title: Systematic Search for Primary Immunodeficiency in Adults With Unexplained Recurrent and/or Severe Infections With Encapsulated Bacteria

Status Terminated

Clinical Trial Summary

Antibody deficiencies and complement deficiencies are the most frequent Primary immunodeficiencies (PIDs) in adults, and are associated with greatly increased susceptibility to recurrent and/or severe bacterial infections - especially upper and lower respiratory tract infections and meningitis. The literature data suggest that PIDs are under-diagnosed in adults. The current European and US guidelines advocate screening adults for PIDs if they present recurrent benign especially upper and lower respiratory tract infections, or if they have experienced at least two severe bacterial infections and/or have a recurrent need for intravenous antibiotics. The objective of the demonstrate the interest of PIDs screening in adult patients who present such recurrent infections and/or after the first severe bacterial infection, especially when the patients do not present with known, etiologically relevant comorbidities.

Clinical Trial Description

n/a

Related Conditions & MeSH terms

• Antibody Deficiency
• Chronic Sinus Infection
• Communicable Diseases
• Complement Deficiency
• Haemophilus Influenza
• Infection
• Meningitis
• Meningitis, Bacterial
• Neisseria Infections
• Otitis Media
• Pneumococcal Infections
• Pneumonia, Bacterial
• Sinusitis
• Streptococcal Infection
• Streptococcal Infections

• NCT number: NCT02972281
• Study type: Interventional
• Source: University Hospital, Lille
• Status: Terminated
• Phase: N/A
• Start date: March 2015
• Completion date: March 2020