CMP-001 in Combination With Nivolumab in Subjects With Advanced Melanoma

Status Completed

Clinical Trial Summary

CMP-001-010 is a Phase 2 study of CMP-001 intratumoral (IT) and nivolumab intravenous (IV) administered to participants with refractory unresectable or metastatic melanoma. The primary objective of the study is to determine confirmed objective response with CMP-001 in combination with nivolumab in subjects with refractory unresectable or metastatic melanoma. The secondary objectives are to: - To evaluate the safety and tolerability of CMP-001 administered by intratumoral (IT) injection in combination with nivolumab in subjects with refractory unresectable or metastatic melanoma. - To evaluate the efficacy of CMP-001 in combination with nivolumab in subjects with refractory unresectable or metastatic melanoma. - To assess the pharmacokinetic (PK) profile of CMP-001 in combination with nivolumab in subjects with refractory unresectable or metastatic melanoma. - To assess and describe the immunogenicity of CMP-001 in combination with nivolumab in subjects with refractory unresectable or metastatic melanoma.

Clinical Trial Description

Former Sponsor Checkmate Pharmaceuticals ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04698187
Study type	Interventional
Source	Regeneron Pharmaceuticals
Contact
Status	Completed
Phase	Phase 2
Start date	March 11, 2021
Completion date	February 5, 2024

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