Study of Trametinib + Ceritinib in Patients With Unresectable Melanoma

Status Active, not recruiting

Clinical Trial Summary

The main purpose of this study is to determine the risks and benefits of ceritinib (ZYKADIA) given in combination with trametinib (MEKINIST) in patients who have progressed on prior melanoma therapy.

Clinical Trial Description

Ceritinib that has been approved for patients with metastatic non-small cell lung cancer (NSCLC) by the US Food and Drug Administration (FDA). While ceritinib is not currently FDA-approved specifically in melanoma, researchers believe ceritinib may also help keep melanoma cancer cells from growing and therefore potentially help patients with melanoma as well. Trametinib is currently FDA-approved for melanoma with a BRAFV600-mutation. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03501368
Study type	Interventional
Source	H. Lee Moffitt Cancer Center and Research Institute
Contact
Status	Active, not recruiting
Phase	Phase 1
Start date	June 27, 2018
Completion date	August 2024

View Details

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