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Combined Therapy of Nivolumab and Adoptive T Cell Therapy in Metastatic Melanoma Patients — Nivo-TIL  

Melanoma Clinical Trial

Official title:
Combined Therapy of Nivolumab and Adoptive T Cell Therapy in Metastatic Melanoma Patients: Pilot Study Phase I/II

Clinical Trial Summary

To improve the efficacy of immunotherapy for cancer, recent studies focused on specific targets to redirect the immune network toward eradicating a variety of tumors and ameliorating the self-destructive process. A clinically relevant immune escape mechanism in melanoma is the activation of the Programmed cell Death-1 (PD-1) receptor on infiltrating T cells. By blocking PD-1 receptors with anti-PD-1 monoclonal antibodies (mAbs), T-cells are unaffected by the PD-L1 expressed on tumor cells and the patients T cells are free to respond to melanoma antigens and attack tumor cells. So the objective of this trial is to evaluate the safety and the efficacy of a combined therapy Nivolumab and adoptive T cell therapy in metastatic melanoma patients.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03374839
Study type Interventional
Source Nantes University Hospital
Contact Amir Khammari, PhD
Phone (+33) (0)2 40 08 32 80
Email amir.khammari@chu-nantes.fr
Status Recruiting
Phase Phase 1/Phase 2
Start date February 12, 2018
Completion date January 2024
View Details
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