Pembrolizumab Effects on NK Cell Exhaustion in Melanoma (Merck NK-IIT)

Status Terminated

Clinical Trial Summary

Melanoma is an immune-modulated malignancy and immune checkpoint modulators which inhibit PD-1 function (pembrolizumab, nivolumab) have demonstrated clinical efficacy as treatment for patients with stage IV melanoma. Pembrolizumab across a range of doses in phase I investigation has demonstrated clinical efficacy with RR approximately 27%. By better understanding how NK cell function and exhaustion interplays with PD1 function and activity, potentially more efficacious combination therapies can be developed. The pharmacodynamic studies to be performed as part of this trial will provide such information.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Melanoma

Clinical Trial Details

NCT number	NCT03241927
Study type	Interventional
Source	Icahn School of Medicine at Mount Sinai
Contact
Status	Terminated
Phase	Phase 2
Start date	December 20, 2017
Completion date	June 6, 2018

View Details

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