Melanoma Clinical Trial
Official title:
A Pilot Study to Evaluate PBR PET in Brain Tumor Patients Treated With Chemoradiation or Immunotherapy
This research study is studying the changes in primary and metastatic brain tumor inflammation using positron emission tomography (PET) imaging using a radioactive substance called [11C] PBR28a, which is also known as peripheral benzodiazepine receptors (PBR), or PBR-PET.
This research study is a Pilot Study, which is the first time investigators are examining
this study intervention. The purpose of a pilot study is to obtain the preliminary data
needed to justify performing a larger clinical trial on the effectiveness of an
investigational intervention.
Standard treatment for the subjects' disease includes chemoradiation and immunotherapy.
In PET scans, a radioactive substance is injected into the body. The scanning machine finds
the radioactive substance, which tends to go to cancer cells and areas of inflammation. For
the PET scans in this study, the investigators are using a radioactive substance called
[11C]PBR28.
The investigators would like to see if this tracer can be used to detect changes in
inflammation during tumor treatment. PBR-PET scans will be performed at screening before
therapy and then several weeks/months after the start of therapy, depending on the type of
therapy used. No diagnostic decisions or clinical treatment decisions will be made based on
any results obtained from these PET scans, and there will be no change in care. The
information from these studies may help the investigators design methods that could be used
in larger studies to more completely understand the role of inflammation in the treatment of
cancer.
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