Transfer of Genetically Engineered Lymphocytes in Melanoma Patients

Status Active, not recruiting

Clinical Trial Summary

This is a phase one trial to determine if genetically engineered lymphocytes can be safely delivered to patients with metastatic melanoma.

Clinical Trial Description

The goal of this study is to establish the recommended phase two dose of autologous T cell receptor transduced T cells when administered with low dose IL-2 to stage IV melanoma patients following a non-myeloablative and lymphodepleting chemotherapy preparative regimen. A secondary objective is to evaluate biologic and immunologic parameters associated with the adoptively transferred T cell receptor transduced T cells, including auditory and visual changes. The investigators believe the infusion of T cell receptor gene modified autologous T cells can mediate objective clinical responses in stage IV melanoma patients. ;

Study Design

Related Conditions & MeSH terms

Melanoma

Clinical Trial Details

NCT number	NCT01586403
Study type	Interventional
Source	Loyola University
Contact
Status	Active, not recruiting
Phase	Phase 1
Start date	July 2012
Completion date	September 2028

View Details

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