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CD8+ T Cell Imaging During Pre-surgery Immunotherapy in People With Melanoma

Melanoma Clinical Trial

Official title:
CD8+ Cell Imaging During Neoadjuvant ImmunoTherapy (The C-IT Neo Trial)

Clinical Trial Summary

Combination treatment with nivolumab and ipilimumab before surgery may help people with melanoma because the drugs are designed to help the immune system target and destroy cancer cells (immunotherapy), which may shrink the cancer and prevent recurrence after surgery. Treatment given before surgery is called neoadjuvant therapy. The purpose of this study is to find out whether neoadjuvant therapy with nivolumab and ipilimumab can kill melanoma tumors before surgery and prevent disease from coming back after surgery. This study also explores a new, experimental PET scan that images the immune system to see if it is related to treatment outcomes.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05289193
Study type Interventional
Source Memorial Sloan Kettering Cancer Center
Contact Michael Postow, MD
Phone 646-888-4589
Email postowm@mskcc.org
Status Recruiting
Phase Phase 2
Start date March 11, 2022
Completion date March 11, 2025
View Details
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