The Influence of Meibomian Gland Expression on Corneal Aberrations in MGD Patients

Meibomian Gland Dysfunction Clinical Trial

Official title:

The Effect of Meibomian Gland Thermal Massage on Corneal Aberrations in Meibomian Gland Dysfunction Patients

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05028491
• Other study ID #: hf-meibomian glands
• Status: Completed
• Start date: October 1, 2020
• Est. completion date: July 29, 2021

Study information

• Verified date: August 2021
• Source: Wenzhou Medical University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

To evaluate the influence of corneal-aberrations before and after the meibomian gland thermal massage treatment.

Description:

62 MGD patients treated with meibomian gland thermal massage once a week for 3 to 4 weeks were recruited.The Ocular Surface Disease Index questionnaire; tear film assessment encompassing tear meniscus height and non-invasive keratograph breakup time ; meibography score,corneal fluorescein staining; the Schirmer I test ; expressible meibomian gland, and quality ,anterior and total corneal aberrations were evaluated before and after treatment.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 62
• Est. completion date: July 29, 2021
• Est. primary completion date: June 29, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 90 Years

Eligibility

Inclusion Criteria:

• tear break-up time (BUT) =10 seconds or Schirmer I test (SIT) =10 mm, the presence of dry eye symptoms, and fluorescein staining (FL) score <3 points and at least one lid margin abnormality and poor meibomian gland expressibility

Exclusion Criteria:

• eyelid structure abnormal(Entropion , ectropion);

• having received any other treatment for MGD within three months

• history of ocular surgery

• contact lens use

• ocular infection

• any type of corneal scarring

Related Conditions & MeSH terms

• Meibomian Gland Dysfunction

Locations

Country	Name	City	State
China	Eye Hospital of Wenzhou Medical College	Wenzhou	Zhejiang

Sponsors (1)

Lead Sponsor	Collaborator
Wenzhou Medical University

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	corneal aberration corneal aberrations	Corneal aberrations were measured with a Pentacam? The anterior corneal wavefront aberration was expanded with normalized Zernike polynomials.The corneal aberration from 3rd to 6th order were recorded as the root mean square (RMS) for analysis.	baseline and 1 week after treatment