Medication Overuse Headache Clinical Trial
Official title:
An Observation Study on Neuropsychology and Serum Melatonin Level in Patients With Medication Overuse Headache
Medication overuse headache (MOH) is a disabling and costly disorder which is characterized
by chronic headache and overuse of different headache medications. Patients with MOH are more
likely to coexist with affective disorders such as anxiety and depression, and are more
likely to suffer from sleep disturbances than those with episodic headache.
Melatonin is a hormone secreted from the pineal gland. Melatonin is an antioxidant,
antinociceptive, hypnotic, anticonvulsant, neuroprotective, anxiolytic, sedative and
analgesic.
This observational study aims to investigate clinical characteristics of patients with MOH
and to explore the relationship between the serum melatonin level and medication overuse
headache. Researchers hope to provide a new idea for the clinical treatment of MOH: melatonin
can be used as an adjuvant therapy for MOH in the future.
30 patients with MOH，30 patients with episodic migraine and 30 age-matched healthy volunteers were recruited in the study. A series of neuropsychological test scale including Hospital Anxiety and Depression Scale (HADS), Pittsburgh sleep quality index (PSQI) and Leeds Dependence Questionnaire (LDQ) were evaluated among all the recruited. Blood samples were taken at 10 a.m. and centrifuged. The serum was separated and collected at −70 °C for the measurement of melatonin . ;
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