Clinical Trials Logo

Clinical Trial Summary

Medication-overuse headache (MOH) is a disabling condition, yet treatable. According to European guidelines and based on evidence, multidisciplinary detoxification is the first choice of treatment for MOH. However, consensus about the details in such detoxification programs is lacking. Contrary, other headache specialists believe more in treating chronic headache with medication overuse with single-therapy of prophylaxis and no withdrawal of acute medication, based on randomized controlled double-blinded placebo trial with prophylaxes. Only a single RCT has compared single-therapy with prophylaxis to detoxification. However there was no significant difference.

AIM:

1. To compare three different treatment protocols in order to improve the therapy of MOH.

2. To test several baseline variables for being potential predictors for good treatment outcome.

3. To examine the role of epigenetics in MOH.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT02993289
Study type Interventional
Source Danish Headache Center
Contact
Status Active, not recruiting
Phase N/A
Start date October 24, 2016
Completion date November 30, 2023

See also
  Status Clinical Trial Phase
Terminated NCT02583425 - Pilot Study of DFN-11 Injection in Medication Overuse Headache Phase 2
Recruiting NCT03655184 - An Observation Study on Neuropsychology and Serum Melatonin Level in Patients With Medication Overuse Headache
Recruiting NCT03671681 - Mindfulness Therapy for Chronic Migraine N/A
Completed NCT01078012 - Short Intervention for Medication Overuse Headache (MOH) - Pilot N/A
Completed NCT03767062 - Peripheral Nerve Block and Topiramate in the Treatment of Medication Overuse Headaches N/A
Recruiting NCT01754571 - CBT in Patients With Medication Overuse Headache Phase 0
Completed NCT02435056 - Medication Overuse Headache (MOH) and an Innovative Approach N/A
Completed NCT01044251 - Frovatriptan as a Transitional Therapy in Medication Overuse Headache Phase 2
Completed NCT00918671 - Medication-overuse Headache: 4 Years Follow up
Completed NCT04336267 - Anodal tDCS in Chronic Migraine With Medication Overuse N/A
Enrolling by invitation NCT01752439 - Effects of Transcranial Direct Current Stimulation in Refractory Chronic Migraine and Medication-overuse Headache N/A
Completed NCT00833209 - Orbitofrontal Cortex (OFC) Influence on Addictive Medication Overuse Headache (MOH) Deriving From Migraine N/A
Recruiting NCT04772742 - Eptinezumab in Adults With Migraine and Medication Overuse Headache Phase 3
Completed NCT04228809 - tDCS in Chronic Migraine With Medication Overuse (Edisom) N/A
Completed NCT04090333 - Endocrinological Profile in Patients With Medication-overuse Headache Before and After Withdrawal Therapy
Recruiting NCT01317992 - Ibudilast in the Treatment of Medication Overuse Headache Phase 1/Phase 2