Mechanical Ventilation Complication Clinical Trial
Official title:
Electrical Impedance Tomography During Spontaneous Breathing Trial and Extubation Failure in Critically Ill Patients: an Observational Study
Weaning is the entire process aimed at liberating patients from mechanical ventilation and
endotracheal intubation. Weaning should be considered as early as possible in order to reduce
the time spent in invasive mechanical ventilation (iMV), which is associated with morbidity
and mortality. To verify if patients are ready to be extubated, a spontaneous breathing trial
(SBT) is performed. At this stage some clinical indices and objective parameters are
evaluated, such as the breathing pattern, gas exchange, haemodynamic stability and patient's
comfort. In case of SBT success, the patient can be extubated. However, a post-extubation
respiratory failure can occur within the first 48 hours after extubation, thus making
extubation unsuccessful. Some patients considered at risk for post-extubation respiratory
failure benefit from the application of non-invasive ventilation (NIV) after extubation.
Early characterization of these patients is crucial to improve their clinical outcomes.
Electrical Impedance Tomography (EIT) has been introduced in clinical practice as a
non-invasive bedside monitoring tool to evaluate the aeration and ventilation of different
lung regions. EIT has been proposed to guide ventilator settings adjustments in critically
ill patients and to monitor prolonged weaning. However, the potential of EIT to assess SBT
and after extubation in a general ICU population has never been evaluated insofar.
The present study aims to describe the modifications of lung aeration, ventilation and
inhomogeneity occurring during SBT and after extubation in a general population of critically
ill patients at the first SBT attempt.
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