Mechanical Ventilation Complication Clinical Trial
Official title:
KIDNEY - LUNG INTERACTION: the Effect of End-expiratory Pressure on Renal Perfusion. Non-invasive Evaluation.
The present study aims to evaluate, with non-invasive methods, the relationships existing between PEEP and renal perfusion in patients undergoing surgery and requiring ventilatory support and monitoring in intensive care. Renal perfusion will be assessed at baseline (PEEP 0), subsequently ,at the application of progressive increases of PEEP. At the end of the measurements, the implications of the use of PEEP on the renal vascular system will be analyzed.
The present physiological, monocentric, observational clinical study evaluates the effect of
progressive PEEP increases on renal perfusion in mechanically ventilated patients who
underwent surgery with the need of ventilatory support and monitoring in intensive care.
Precisely, will be evaluated:
- The morphometric parameters (coronal diameter and cortico-medullary thickness) and the
renal resistive indices (IR). The inter-lobar arteries will be sampled and the IRs will
be measured as the upper and lower level and the mesorenes. Measurements will be
performed both in the kidney and in baseline conditions and incremental values of PEEP
(0 - 6 - 12).
- Gas exchanges, FC, systolic BP, diastolic and mean, Pmax, P1 and P2 of the airways,
total and ohmic resistances and static respiratory compliance indexed for weight body
(RRSmaxI, RRSminI, CrsI will be recorded).
The intra-class correlation coefficient will be measured to estimate the intra-observer
reproducibility of the conducted measurement.
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