Mean Blur Ratio Clinical Trial
Official title:
Optic Nerve Head Blood Flow Regulation During Isometric Exercise in Patients With Normal Tension Glaucoma
Glaucoma is the second leading cause of blindness worldwide. Literature shows increasing
evidence that dysfunction of ocular microcirculation in the optic nerve influences the
progression of glaucoma. It has been shown that flicker light-induced vasodilatation of
retinal veins is diminished in patients with glaucoma. Also previous studies indicate that
the blood flow autoregulation is impaired in patients with glaucoma. Therefor the ocular
perfusion pressure can not be maintained stable during changes of the systemic arterial blood
pressure. Laser speckle flowgraphy (LSFG) represents a non-invasive method to quantify ocular
perfusion also at the ONH. LSFG enables noninvasive quantification of microcirculation of the
optic disc in Japanese glaucoma patients.
Study Objectives:
To assess the changes in LSFG parameters in patients with normal tension glaucoma, compared
to healthy subjects during flicker light stimulation and isometric exercises.
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