MCI Clinical Trial
Official title:
Amyloid PET in Patients With Mild Cognitive Impairment and Early Dementia
NCT number | NCT06402370 |
Other study ID # | ONZ-2023-0444 |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | May 8, 2024 |
Est. completion date | May 2026 |
The National Institute on Aging together with the Alzheimer's Association (NIA-AA) recently proposed the ATN classification which is based upon the pathological processes present in Alzheimer's disease (amyloid, tau and neurodegeneration). The amyloid and tau status can be defined using cerebrospinal fluid analysis but also non-invasively using an amyloid or tau PET scan. The N status can be defined using an [18F]-FDG PET scan which is in Belgium part of standard of care. Recently, it has been demonstrated, using different amyloid PET tracers, that early-frame amyloid scans can be a surrogate for [18F]-FDG PET scan.
Status | Recruiting |
Enrollment | 50 |
Est. completion date | May 2026 |
Est. primary completion date | May 2026 |
Accepts healthy volunteers | |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Patients with mild cognitive impairment or early stage dementia who have a MRI and [18F]FDG PET/CT scan as part of routine clinical work-up Exclusion Criteria: - Patient is not able to understand the study Patient is not able to lie still in the scanner for at least 30 minutes Pregnancy or breastfeeding |
Country | Name | City | State |
---|---|---|---|
Belgium | Van Weehaeghe D | Gent |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Ghent |
Belgium,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | N-status | N-status can be determined using ultrashort early frame amyloid scans of 1 minute | 2 years | |
Primary | A-status | A-status can be determined with a one minute scan 60-90 minutes after injection | 2 years |
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