Prevalence of May-Thurner Syndrome in 1st-degree Relatives of Symptomatic Patients

May-Thurner Syndrome Clinical Trial

— MTS  

Official title:

Prevalence of May-Thurner Syndrome in 1st-degree Relatives of Symptomatic Patients

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05409781
• Other study ID #: DVS002
• Status: Not yet recruiting
• Start date: August 15, 2024
• Est. completion date: January 15, 2025

Study information

• Verified date: April 2024
• Source: University Hospital of Limerick
• Contact: Fiona Leahy, MSc
• Phone: 061588394
• Email: fionac.leahy[@]hse.ie
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

The aim is to assess the prevalence of May-Thurner syndrome in 1st-degree relatives of previously identified symptomatic patients.

Description:

May-Thurner syndrome (MTS) is a condition characterised by compression of the left common iliac vein by the right common iliac artery and the anterior spine of the 5th lumbar vertebrae. Previously thought to be a rare condition, the prevalence of MTS is thought to be underreported. MTS can lead to significant morbidity in the form of chronic venous insufficiency, venous ulceration, lower limb swelling, venous claudication, deep-vein thrombosis, varicose veins, pelvic congestion syndrome, chronic pelvic pain and chronic post-thrombotic syndrome. It is a known risk factor for development of venous incompetence and varicose veins in adolescents and young adults. Furthermore, it is known to be an a causative factor in the development of "unprovoked" DVT in younger patients, however data on the risk of development of DVT in MTS patients has to date, been unavailable.

The pathogenesis of MTS is largely unknown and whilst the condition is known to be more prevalent in females, familial risk factors are largely unknown. To date, no studies have previously assessed the prevalence of MTS in relatives of those with the condition.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 50
• Est. completion date: January 15, 2025
• Est. primary completion date: December 15, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Informed consent, first degree relative with symptomatic May-Thurner syndrome

Exclusion Criteria:

• Those who not give informed consent to be contacted or to be scanned.

Related Conditions & MeSH terms

• May-Thurner Syndrome
• Syndrome

Intervention

Other:
• No Intervention
No Intervention

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital of Limerick

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Prevalence Assessment	To assess the prevalence of May-Thurner syndrome amongst 1st-degree relatives of symptomatic individuals referred to the Vascular Department, University Hospital Limerick using duplex ultrasound imaging	1 year
Secondary	Venous Competence Assessment	To assess concomitant venous incompetence of the lower limb	1 year