Clinical Trial Details
— Status: Completed
Administrative data
NCT number |
NCT05293990 |
Other study ID # |
2017GR0776 |
Secondary ID |
|
Status |
Completed |
Phase |
N/A
|
First received |
|
Last updated |
|
Start date |
February 2, 2017 |
Est. completion date |
January 25, 2021 |
Study information
Verified date |
March 2022 |
Source |
Korea University Guro Hospital |
Contact |
n/a |
Is FDA regulated |
No |
Health authority |
|
Study type |
Interventional
|
Clinical Trial Summary
Polyplastic glioblastoma and metastatic brain cancer are the most common malignant brain
tumors in adults. The primary diagnostic test for tumors in the brain shows magnetic
resonance imaging or similar imaging findings (especially single metastatic brain cancer)
that make it difficult to distinguish between these two diseases. In addition, due to the
specificity of the tissue called the brain, biopsy is not easy and sometimes biopsy is
difficult, so non-invasive discrimination is often important, and it is important how much
prediction is made before the biopsy. To solve this problem, various advanced magnetic
resonance imaging techniques have been studied, but they are all tests that need to be
additionally conducted on ordinary magnetic resonance images, and there are many subjective
factors, so complex data and statistical processing methods, and many cannot be easily
tested. In addition, in all of these tests, accuracy is still reported at around 60%.
Therefore, if contrast-enhanced FLAIR images can be obtained along with contrast-enhanced T1
images performed during conventional magnetic resonance imaging tests to help differentiate
between two diseases, it will greatly help diagnose and treat brain tumor patients and
facilitate clinical application.
Description:
Polyplastic glioblastoma and metastatic brain tumors are the most common brain tumors in
adults. Polyplastic glioblastoma is the most common tumor among malignant primary brain
tumors, and metastatic brain tumors are the most common brain tumors in adults. In the
diagnosis of brain tumors, magnetic resonance imaging is the most basic and primary imaging
technique to date. However, in the case of a single metastatic brain tumor, the tumor shape,
signal intensity, contrast enhancement pattern, and peripheral signal intensity appear so
similar that they are hardly distinguished from polymorphic glioblastoma in conventional
magnetic resonance images. However, it is very important to distinguish between the two
diseases because the above two diseases have completely different characteristics in clinical
aspects, surgical method decisions, treatment decisions, and prognosis. Obtaining
histological results will be the ultimate answer, but due to the nature of tissue called the
brain, non-invasive tests are preferred, and sometimes patients (e.g., cardiovascular
disease) or lesions themselves cannot handle surgery are in a very important part of the
brain, so it depends on imaging techniques. In addition, the distinction between the two
diseases through imaging is important in that it is important to predict in advance even if
biopsy is performed through surgery. Therefore, various advanced magnetic resonance imaging
techniques such as diffusion-enhanced imaging (DWI), perfusion imaging (perfusion), and
spectroscopic imaging (MR spectroscopy) have been attempted to better differentiate the two
diseases through imaging tests. However, these images are additional imaging tests that need
to be obtained after obtaining conventional magnetic resonance images and are usually
accompanied by complex and various statistical analyses due to many subjective elements. In
addition, there are tests that are difficult to conduct other than large hospitals with a
certain size or larger. Nevertheless, the accuracy of the discrimination between the two
diseases to date is around 60%. In addition, such tests are often difficult to perform in
most hospitals, except for large hospitals with a certain size or larger. Therefore, if the
two diseases can be better identified in conventional magnetic resonance imaging, it will be
of great help to patient care clinically and it is expected that actual clinical application
will be easier. Contrast-enhanced T1 highlighted images are always performed in conventional
magnetic resonance images, and after that, one more FLAIR image is obtained to see if
contrast-enhanced FLAIR images are helpful in differentiating the two diseases.