Clinical Trials Logo

Clinical Trial Summary

Malignant tumor incidence showed an upgrade trend in recent years. Standard therapy for malignant tumor includes surgery followed by radiation and chemotherapy. Despite optimal treatment the prognosis remains poor. There is an urgent need for more effective therapies. The Warburg effect has been widely observed in human cancers. The main energy supply of tumor cells are aerobic glycolysis. Therefore, they are highly dependent on glucose metabolism. Recently, some scholars have suggested that 'Restricted calorie Ketogenic Diet (RKD)' might be able to inhibit glycolysis and thus anti-tumor by restricting carbohydrate intake. This will 'starve' cancer cells, which will lead to cell death. There are many animal and in vitro studies shown that RKD can reduce the tumor size and thus tumor cell growth of malignant tumors. However, a consistent positive result can not be found within a small sample of clinical trials. In this study, 40 patients with malignant tumors will be treated with or without RKD. The safety and efficacy of RKD and the patients' tolerance will be observed in order to understand whether this therapy can be a potential new treatment This clinical study is comparatively large internationally. It is the first domestically. This study is essential to extend the survival of patients with malignant tumors, and to study clinical nutrition support and its metabolic pathways for malignant tumors.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03160599
Study type Interventional
Source Second Affiliated Hospital of Guangzhou Medical University
Contact Yu Hong Deng, M.D.
Phone 86 20 81340031
Email 1376708863@qq.com
Status Recruiting
Phase N/A
Start date March 1, 2018
Completion date December 1, 2020

See also
  Status Clinical Trial Phase
Completed NCT02041871 - Interest of PReOPerative Immunonutrition in Liver Surgery for Cancer N/A
Completed NCT03110783 - Bioseal Dural Sealing Study BIOS-14-001 Phase 3
Recruiting NCT05516914 - A Phase Ib/II Clinical Trial of LBL-007 Combined With Tislelizumab in the Treatment of Malignant Tumors Phase 1/Phase 2
Completed NCT02534506 - Study of Urelumab in Subjects With Advanced and/or Metastatic Malignant Tumors Phase 1
Recruiting NCT05714748 - Application of mRNA Immunotherapy Technology in Epstein-Barr Virus-related Refractory Malignant Tumors Phase 1
Recruiting NCT05987098 - BBPA PET/CT in Patients With Malignant Tumors N/A
Not yet recruiting NCT01092247 - The Effect of Ketogenic Diet on Malignant Tumors- Recurrence and Progress N/A
Recruiting NCT04702841 - CAR - γ δ T Cells in the Treatment of Relapsed and Refractory CD7 Positive T Cell-derived Malignant Tumors Early Phase 1
Completed NCT00165100 - Dynamic Area Telethermometry (DAT) as an Imaging Modality in Patients With Cancer N/A
Suspended NCT05615974 - A Phase I/II Study of LM-101 Injection in Patients With Advanced Malignant Tumors Phase 1/Phase 2
Completed NCT03542773 - Targeted Imaging of Glutamate Carboxypeptidase II With DCFPyL-PET Phase 1
Completed NCT05293990 - Usefulness of Gadovist-enhanced FLAIR Imaging N/A
Completed NCT01509612 - Additive Homeopathy in Cancer Patients Phase 3
Completed NCT01678690 - An Exploratory Study of Gemcitabine Hydrochloride Oral Formulation (D07001-F4) in Subjects With Malignant Tumors Phase 0
Suspended NCT06270394 - FAP PET/CT or PET/MR Production in the Diagnosis, Staging, and Efficacy Assessment of Malignant Tumors Application N/A
Completed NCT00412503 - Temozolomide in Association With Topotecan in Refractory or Relapsed Malignant Tumors in Children and Adolescents Phase 1