Malignant Tumor Clinical Trial
Official title:
Effect of Intraoperative Dexmedetomidine on Development of Acute Kidney Injury Following Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy: a Double-blind Randomized Clinical Trial
To investigate the renal protective effect of dexmedetomidine in patients undergoing cytoreduction and hyperthermic intraperitoneal chemotherapy
A cytoreductive surgery and hyperthermic intraperitoneal chemotherapy may lead to the renal hypoperfusion, systemic inflammatory response, and oxidative stress. Dexmedetomidine has been known to protect the kidney against inflammation and oxidative stress in diverse clinical settings. It may also enhance a renal perfusion by inhibition of renal sympathoexcitation. We hypothesized administration of dexmedetomidine might protect the kidney in patients undergoing cytoreduction and hyperthermic intraperitoneal chemotherapy. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04691349 -
CAR-T for r/r Malignant Tumors in Children
|
Early Phase 1 | |
| Recruiting |
NCT04672473 -
Treatment of Malignant Tumors With Antigen Peptide-specific DC-CTL Cells and Decitabine
|
Phase 1/Phase 2 | |
| Recruiting |
NCT06080984 -
The Application of Novel Oncolytic Virus in Late Stage Solid Tumors
|
Phase 1 | |
| Recruiting |
NCT04991506 -
A Study of ES102 (OX40 Agonist) in Combination With JS001 in Patients With Advanced Solid Tumors
|
Phase 1 | |
| Completed |
NCT02552004 -
Assessment of Intraoperative Probe-based Confocal Laser Endomicroscopy in Digestive and Endocrine Surgery: a Pilot Study
|
N/A | |
| Recruiting |
NCT05280873 -
Pirfenidone Combined With Methylprednisolone Versus Methylprednisolone in the Treatment of CIP
|
Phase 1 | |
| Completed |
NCT06093945 -
Effect of Omeprazole on Pharmacokinetics of SHR2554 in Healthy Subjects
|
Phase 1 | |
| Completed |
NCT05592262 -
Pharmacokinetic Test of High-fat Diet After Oral Administration of SHR2554 in Healthy Subjects
|
Phase 1 | |
| Completed |
NCT03012945 -
Epidural Anesthesia-analgesia and Long-term Outcome
|
N/A | |
| Recruiting |
NCT04686682 -
A First-in-Human, JAB-8263 in Adult Patients With Advanced Tumors
|
Phase 1/Phase 2 | |
| Recruiting |
NCT06084767 -
68Ga-TCR-FAPI PET/CT in Patients With Various Types of Cancer
|
N/A | |
| Enrolling by invitation |
NCT02937246 -
Efficacy of Partial Covered Double Bare Metal Stent Compared to Uncovered Double Bare Metal Stent in Malignant Biliary Obstruction
|
N/A | |
| Completed |
NCT03354741 -
Stimulation of Acupuncture Points by Athermic Laser Therapy for the Prevention of Chemotherapy Induced Nausea and Vomiting in Children
|
N/A | |
| Recruiting |
NCT03931720 -
Clinical Research of ROBO1 Specific BiCAR-NK/T Cells on Patients With Malignant Tumor
|
Phase 1/Phase 2 | |
| Completed |
NCT01906632 -
Gene Expression Profiling of Malignant Tumor Predict the Therapeutic Response of DC-CIK Immunotherapy
|
N/A | |
| Recruiting |
NCT05596344 -
Long-term Follow-up of Anxiety and Depression in Patients With Malignant Tumors
|
||
| Active, not recruiting |
NCT04230200 -
Prospective Screening Programme for Malignant Tumors
|
||
| Completed |
NCT04730843 -
A Study of ES102 (OX40 Agonist) in Patients With Advanced Solid Tumors
|
Phase 1 | |
| Completed |
NCT04952766 -
Study Evaluating SARS-CoV-2 (COVID-19) Humoral Response After BNT162b2 Vaccine in Immunocompromised Adults Compared to Healthy Adults
|
Phase 4 | |
| Recruiting |
NCT05781555 -
A Study of Diffusing Alpha Radiation Therapy for Target Treatments of Malignant Tumors
|
N/A |