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Provider-Mediated Communication of Genetic Testing Results to At-Risk Relatives of Cancer Patients to Improve Genetic Counseling and Testing Rates, Family HOPE Study

Malignant Solid Neoplasm Clinical Trial

Official title:
Family HOPE Study (Hereditary Lynch Syndrome Opportunities for Participation &Amp; Engagement)

Clinical Trial Summary

This clinical trial tests whether provider-mediated communication of genetic testing results to at-risk relatives of cancer patients can help improve genetic counseling and testing rates. Approximately 15% of people with cancer have an inherited form of cancer due to changes in a gene that they have inherited from one of their parents. These changes increase a person's risk for developing cancer. Most people who have an inherited harmful change in a cancer risk gene don't know that they have it and are therefore not able to get the health care that they need. The primary reason for this problem has been a lack of genetic counseling and testing for cancer patients and patients with a strong family history of cancer. Another reason for this lack of awareness is that, when cancer runs in a family, the patient who carries the gene change usually has to communicate the genetic risk information to their family members. When this process doesn't work well, family members may not know that they need to get genetic testing and then may not get potentially life-saving care. Provider-mediated contact to discuss genetic test results may help improve rates of genetic testing among at-risk relatives of patients with a family cancer syndrome.

Clinical Trial Description

PRIMARY OBJECTIVES: I. Improve rates of family member cascade testing. II. Evaluate the psychosocial impact of provider-mediated contact to communicate genetic testing results. OUTLINE: Participants are randomized to 1 of 2 arms. ARM I: Patients receive a family letter and their genomic test report to share with at-risk first degree relatives on study. ARM II: Patients receive a family letter and their genomic test report to share with at-risk first degree relatives and relatives also receive provider-mediated contact to discuss genetic results on study. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05772130
Study type Interventional
Source City of Hope Medical Center
Contact
Status Recruiting
Phase N/A
Start date February 14, 2023
Completion date December 14, 2025
View Details
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