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Study of Nivolumab and Ipilimumab in Children and Young Adults With INI1-Negative Cancers

Epithelioid Sarcoma Clinical Trial

Official title:
Phase 2 Proof of Concept Study of Nivolumab and Ipilimumab in Children and Young Adults With Relapsed or Refractory INI1-negative Cancers

Clinical Trial Summary

This clinical trial is studying two immunotherapy drugs (nivolumab and ipilimumab) given together as a possible treatment for INI1-negative tumors.

Clinical Trial Description

This research study is a Phase II clinical trial, which tests the safety and effectiveness of an investigational drug or drug combination to learn whether the drug or drug combination works in treating a specific disease. "Investigational" means that the drug combination is being studied. The names of the study drugs involved in this study are: - Nivolumab (OPDIVO) - Ipilimumab (YERYOY) This trial is studying whether nivolumab and ipilimumab work to treat INI1-negative cancers. The U.S. Food and Drug Administration (FDA) has not approved combination nivolumab and ipilimumab for the specific diseases in this study but it has been approved for other diseases. Nivolumab and ipilimumab have been tested in children to find out a safe dose of this combination. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04416568
Study type Interventional
Source Dana-Farber Cancer Institute
Contact Suzanne Forrest, MD
Phone (617) 632-6443
Email suzanne_forrest@dfci.harvard.edu
Status Recruiting
Phase Phase 2
Start date August 14, 2020
Completion date October 2025
View Details
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