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Nivolumab in Patients With Recurrent Malignant Mesothelioma — NivoMes  

Malignant Pleural Mesothelioma Clinical Trial

Official title:
A Single Arm Phase II Study of Nivolumab in Patients With Recurrent Malignant Pleural Mesothelioma: Interim Biopsy Analysis to Determine Efficacy. Acronym: NivoMes Study

Clinical Trial Summary

This is a prospective, single arm, phase II trial in previously treated patients with MPM who are considered candidates for immunotherapy and repeat thoracoscopies/transthoracic biopsies. Nivolumab will be administered 3 mg/kg q2 weeks by intravenous injection.

The administration of nivolumab as monotherapy will improve DCR form 20% to 40% at 12 weeks when compared to DCR of patients treated with best supportive care based on historical controls.

Clinical Trial Description

Patients will undergo pre- and post-treatment thoracoscopies/biopsies. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02497508
Study type Interventional
Source The Netherlands Cancer Institute
Contact
Status Completed
Phase Phase 2
Start date July 2015
Completion date July 2017
View Details
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