Malignant Melanoma Clinical Trial
Official title:
Prevention of Recurrence and Metastasis in Genetically High-Risk Melanomas
The purpose of this study is to determine whether a medication, fluvastatin, can change
melanoma to a state that is less likely to metastasize or recur.
Fluvastatin is experimental in this setting because it is not approved by the Food and Drug
Administration (FDA) for treatment or prevention of melanoma. However, fluvastatin has been
approved by the FDA for treating high cholesterol.
This is an open-label, single arm, study assessing the activity of fluvastatin in shifting
the transcriptome in melanoma. Subjects with melanoma will be asked to participate and all
subjects will receive the study drug, fluvastatin, for 2 weeks.
The primary objective of this study to determine whether administration of fluvastatin
changes the melanoma transcriptome
The secondary objective of this study is to determine whether administration of fluvastatin
changes the gene expression profile of Class 2 melanoma to Class 1 melanoma.
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