Malignant Melanoma Clinical Trial
Official title:
High Intensity Interval Training (HIIT) on Stationary Bike With and Without Compression Stockings for Patients With Cancer-related Lymphedema in the Lower Limbs - a Feasibility Study
The aim of the study is to explore the feasibility and safety of High Intensity Interval
Training on a stationary bike for patients with lymphedema in the lower limbs and the role of
compression garments during exercise.
The design of the study is a cross-over randomized clinical trial. Participants will be
randomized into two groups. Both will perform two separate exercise sessions.Group A will
perform the first exercise with compression garment and the second session without
compression garment, with wash-out period of 1 week between sessions. Group B will perform
the exercise sessions in the opposite order.
Lymphedema is a condition afflicting cancer patients who undergo surgery with removal of
lymph nodes, chemotherapy and radiation. Lymphedema is a consequence of impaired lymphatic
drainage in the interstitium, which causes edema and inflammation in the subcutaneous tissue.
The symptoms are swelling, puffiness, tightness, heaviness and pain in the affected area.
Lymphedema can be reduced by complete decongestive therapy, which consists of skin care,
manual lymphatic drainage, compression bandaging and exercise. At the end of treatment,
patients are provided with custommade compression garments to be worn during daytime in order
to maintain the reduction in the edema.
Lymphedema has a negative impact on activities of daily living and health-related quality of
life. Patients with lymphedema should be encouraged to engage in physical activity despite
their condition in order to prevent relapse of cancer and development of other diseases.
Likewise physical activity helps to maintain a healthy weight, which is important as obesity
has a negative impact on lymphedema. The lymphatic system is also stimulated by physical
activity and exercise and can reduce the symptoms from the lymphedema.
Several studies have been published on the safety and benefits of exercise for women with
breastcancer related lymphedema. However, only a few studies have investigated the
feasibility of exercise to patients with lymphedema in the lower limbs. Also the role of
compression garments during exercise have not been throughly explored.
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