Stage IV Breast Cancer Clinical Trial
Official title:
A Randomized Phase I Trial of Nanoparticle Albumin Bound Paclitaxel (Nab-paclitaxel, Abraxane) With or Without Mifepristone for Advanced Breast Cancer
This trial will find the best dose of mifepristone when given together with nab-paclitaxel
(Abraxane) based on the side effects of the two drugs in patients with advanced breast
cancer.
Patients will be randomized to receive nab-paclitaxel with or without mifepristone during the
first treatment cycle. After the first cycle, all patients will receive nab-paclitaxel with
mifepristone until their disease worsens or they experience an unacceptable side effect.
This study will test up to 4 doses of mifepristone in combination with nab-paclitaxel. The
study will first test the lowest dose in a small group of patients and if they do not have
bad side effects, higher doses will be tested.
n/a
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