Malaria in Pregnancy Clinical Trial
Official title:
Effectiveness of Intermittent Screening and Treatment of Malaria in Pregnancy (ISTp) on Maternal and Birth Outcomes in Selected Districts in Rwanda
The main aim of this study is to test the primary hypothesis that the addition of intermittent screening and treatment of malaria in pregnant women (ISTp) who receive routine antenatal care (ANC) in health facilities in high malaria transmission areas in Rwanda will reduce malaria prevalence among pregnant women when compared to routine antenatal cares services alone.
More specifically, the primary objective is to understand the effect of ISTp in a context
where routine antenatal care does not include malaria chemoprohylaxis and whether this
intervention is protective against malaria during pregnancy. The secondary objective is to
determine whether this intervention results in an improvement in other key maternal and
newborn health outcomes including maternal anemia, low birth weight and prematurity. The
third objective is to determine the feasibility, effectiveness and acceptability of ISTp
among women who receive ISTp and among health workers who deliver this intervention.
This study will establish if testing and treating pregnant women is effective, feasible and
whether it adds an additional burden to the work already being undertaken by facility-based
health workers who provide antenatal care services. It is expected that the study will result
in information to develop appropriate approaches that can be implemented in Rwanda in the
prevention of malaria in pregnancy in addition to the use of preventive measures such as
insecticide treated mosquito nets (ITNs) and case management. This information may
potentially also be used by other countries with similar patterns of malaria transmission.
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