Clinical Trials Logo

Clinical Trial Summary

The main aim of this study is to test the primary hypothesis that the addition of intermittent screening and treatment of malaria in pregnant women (ISTp) who receive routine antenatal care (ANC) in health facilities in high malaria transmission areas in Rwanda will reduce malaria prevalence among pregnant women when compared to routine antenatal cares services alone.


Clinical Trial Description

More specifically, the primary objective is to understand the effect of ISTp in a context where routine antenatal care does not include malaria chemoprohylaxis and whether this intervention is protective against malaria during pregnancy. The secondary objective is to determine whether this intervention results in an improvement in other key maternal and newborn health outcomes including maternal anemia, low birth weight and prematurity. The third objective is to determine the feasibility, effectiveness and acceptability of ISTp among women who receive ISTp and among health workers who deliver this intervention.

This study will establish if testing and treating pregnant women is effective, feasible and whether it adds an additional burden to the work already being undertaken by facility-based health workers who provide antenatal care services. It is expected that the study will result in information to develop appropriate approaches that can be implemented in Rwanda in the prevention of malaria in pregnancy in addition to the use of preventive measures such as insecticide treated mosquito nets (ITNs) and case management. This information may potentially also be used by other countries with similar patterns of malaria transmission. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03508349
Study type Interventional
Source Jhpiego
Contact
Status Completed
Phase N/A
Start date September 5, 2016
Completion date March 18, 2019

See also
  Status Clinical Trial Phase
Completed NCT01053325 - Establishing Effectiveness of Daily Co-trimoxazole Prophylaxis For Prevention of Malaria in Pregnancy Phase 3
Completed NCT00140517 - Relationships Between the Use of Antimalarial Drugs in Pregnancy and Plasmodium Falciparum Resistance N/A
Recruiting NCT05306067 - Plasmodium Falciparum Genomic Intelligence in Mozambique
Recruiting NCT05757167 - Improving Neonatal Health Through Rapid Malaria Testing in Early Pregnancy With High-Sensitivity Diagnostics Phase 4
Active, not recruiting NCT01555255 - Malaria Rapid Diagnostic Tests (RDTs) in Pregnancy: Detection of Placental Malaria N/A
Completed NCT01136850 - Intermittent Preventive Treatment With Azithromycin-containing Regimens in Pregnant Women in Papua New Guinea Phase 3
Terminated NCT04148690 - Assessing the Impact of Group Antenatal Care on IPTp Uptake in Tanzania N/A
Completed NCT04160026 - Acceptability and Feasibility in the Context of the IMPROVE Trial in Kenya Phase 4
Completed NCT04783051 - Comparison of ISTp- PYRAMAX-US-RDT to IPTp-SP to Prevent Malaria in Pregnant Women in DRC (ULTRAPYRAPREG) Phase 3
Not yet recruiting NCT05348746 - ERASE - Impact of COVID-19 on Malaria Control
Completed NCT03998839 - TIPTOP Sulfadoxine-pyrimethamine (SP) Drug Resistance Study
Completed NCT03208179 - Improving PRegnancy Outcomes With Intermittent preVEntive Treatment in Africa Phase 3
Completed NCT01120145 - Assessment of Sulphadoxine-pyrimethamine for Intermittent Preventive Treatment of Malaria in Pregnancy in Malawi N/A
Completed NCT00730366 - New Approaches to Improve Coverage and Compliance of Antimalarial Treatment for Pregnant Women in Rural Africa Phase 3
Completed NCT00852423 - Safe and Efficacious Artemisinin-based Combination Treatments for African Pregnant Women With Malaria Phase 3
Completed NCT00680732 - Prevention of Intrauterine Growth Retardation in Burkina Faso: the Malaria Component Phase 4
Recruiting NCT03754322 - LAMP Detection of Malaria in PREGnancy (LAMPREG) Trial N/A
Not yet recruiting NCT03944317 - Azithromycin (AZ) and Sulphadoxine-pyrimethamine (SP) for Malaria Prevention in Pregnant Women (IPT-AZ/IPT-SP) N/A
Completed NCT05294406 - Intermittent Preventive Treatment With Dihydroartemisinin-piperaquine in Papua, Indonesia Phase 4
Recruiting NCT04825782 - MiMBa Pregnancy Registry