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Maintenance Therapy clinical trials

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NCT ID: NCT06341556 Recruiting - Clinical trials for Mantle Cell Lymphoma

A Multicenter, Prospective, Phase II Study of Zanubrutinib for Maintenance in Patients With Mantle Cell Lymphoma

Start date: April 2024
Phase: Phase 2
Study type: Interventional

This study aims to evaluate whether maintenance therapy with Zanubrutinib monotherapy could improve the 2-year progression free survival (PFS) of patients with mantle cell lymphoma who had remission after first-line immunochemotherapy

NCT ID: NCT06277050 Recruiting - Clinical trials for Nasopharyngeal Carcinoma

Maintenance Therapy With Toripalimab and Capecitabine Versus Capecitabine Alone in High-risk Nasopharyngeal Carcinoma

Start date: March 7, 2024
Phase: Phase 3
Study type: Interventional

N3 classification, rENE positivity is a high-risk type of locally advanced nasopharyngeal carcinoma. EBV DNA remaining at detectable levels after induction chemotherapy is also a characteristic of high-risk nasopharyngeal carcinoma. Based on the available evidence, patients with high-risk nasopharyngeal carcinoma are recommended to receive oral maintenance therapy to reduce the risk of failure. The purpose of this study was to conduct a prospective, multicenter, randomized phase III clinical trial to determine whether maintenance therapy with triprilimab combined with capecitabine is better than maintenance therapy with capecitabine alone in high-risk nasopharyngeal carcinoma (N3+, rENE+, Detectable EBV DNA after 2 cycles of induction chemotherapy).

NCT ID: NCT05965284 Recruiting - Clinical trials for ANCA-associated Vasculitis

Efficacy and Safety for Telitacicept in the Remission Maintenance Treatment of ANCA-associated Vasculitis (TTCAZAREM)

Start date: March 9, 2023
Phase: Phase 4
Study type: Interventional

This study is a prospective, open-labelled, randomized, controlled, single-center clinical trial. The aim of this study is to compare the remission rate of patients treated with Telitacicept combined with azathioprine and azathioprine alone in remission-maintenance treatment of AAV.

NCT ID: NCT05869227 Recruiting - Clinical trials for Nasopharyngeal Carcinoma

Maintenance Therapy With Toripalimab Combined With Capecitabine/Placebo for Recurrent and Metastatic Nasopharyngeal Carcinoma

Start date: April 28, 2023
Phase: Phase 3
Study type: Interventional

The aim of this study is to investigate the efficacy and safety of the "capecitabine combined with toripalimab maintenance regimen" in improving the first-line treatment of recurrent and metastatic nasopharyngeal carcinoma after receiving remission through chemotherapy combined with anti PD-1 monoclonal antibody standard regimen.

NCT ID: NCT04737343 Recruiting - Clinical trials for ANCA Associated Vasculitis

Comparison of the Efficacy of Leflunomide and Azathioprine for the Maintenance Therapy of ANCA Associated Vasculitis

LEFAZAREM
Start date: June 30, 2021
Phase: N/A
Study type: Interventional

This study is a prospective, open-labelled, randomized, controlled,multi-center clincial trial. The aim of this study is to verify that the remission rate of patients treated with Leflunomide is not inferior to that of patients treated with Azathioprine.

NCT ID: NCT04552912 Completed - Physical Activity Clinical Trials

Physical Activity to Improve Patient Reported Outcomes for Adults With Acute Leukemia

Build Stamina
Start date: January 15, 2021
Phase: N/A
Study type: Interventional

The purpose of this study is to test the efficacy of an evidence-based tailored physical activity program adapted for adults with acute leukemia. Implementation-related process evaluation of the physical activity program will also be assessed.

NCT ID: NCT03384459 Recruiting - Vitiligo Clinical Trials

Maintenance Therapy of 308-nm Excimer Laser Therapy in Patients With Vitiligo

Start date: November 18, 2017
Phase: N/A
Study type: Interventional

Although vitiligo is difficult to cure, recurrences are frequent after treatment, and many patients suffer from concerns about recurrence as well as disease. Psoriasis, another indication for ultraviolet radiation treatment, has been established that it can safely and effectively reduce the recurrence of psoriasis through monthly maintenance therapy. The aim of this study was to evaluate the efficacy of 308-nm excimer laser therapy for the prevention of relapse in vitiligo.

NCT ID: NCT03384342 Recruiting - Vitiligo Clinical Trials

Maintenance Therapy of Narrow-band UV-B Therapy in Patients With Vitiligo

Start date: November 18, 2017
Phase: N/A
Study type: Interventional

Although vitiligo is difficult to cure, recurrences are frequent after treatment, and many patients suffer from concerns about recurrence as well as disease. Psoriasis, another indication for ultraviolet radiation treatment, has been established that it can safely and effectively reduce the recurrence of psoriasis through monthly maintenance therapy. The aim of this study was to evaluate the efficacy of Narrow-band UV-B therapy for the prevention of relapse in vitiligo.

NCT ID: NCT03160105 Completed - HIV-1-infection Clinical Trials

Evaluation of a Simplified Strategy for the Long-term Management of HIV Infection (Simpl'HIV)

Simpl'HIV
Start date: May 19, 2017
Phase: Phase 4
Study type: Interventional

The purpose of this study is to evaluate whether maintenance antiretroviral therapy could be simplified to DTG + FTC dual therapy and/or patient-centered monitoring once virological suppression is achieved. Using a factorial design, the study aims to assess the efficacy of DTG + FTC dual therapy to maintain virological suppression through 48 weeks of follow-up as well as the costs of a patient-centered ART laboratory monitoring.