Neuromuscular Blockade Clinical Trial
Official title:
Effect of Pre-treatment With Magnesium Sulfate on the Duration of Deep Neuromuscular Blockade With Rocuronium: Random and Double-blind Clinical Study
It is a prospective, comparative, randomized, double-blind clinical trial whose hypothesis
is that pre-treatment with magnesium sulfate, due to its action at the neuromuscular
junction,potentiate the duration of deep neuromuscular block following rocuronium
curarization in patients undergoing general anesthesia. Magnesium sulphate has gained
prominence as an adjuvant drug in anesthesia. Its use is associated with potentiation of
neuromuscular blockade among other functions.
The deep neuromuscular block is defined as the one obtained by the absence of response to
the sequence of four Stimuli and the presence of one or more simple stimuli in post-tetanic
counts . There is no literature description of the role of magnesium sulphate in Duration of
the deep neuromuscular block obtained after the muscle relaxation of patients with
rocuronium This study is justified because extending the clinical duration of neuromuscular
blockers may translate into gains for surgeries that require deep and long-lasting muscle
relaxation as in laparoscopic and robotic surgeries. This block allows lower inflation
pressures of the pneumoperitoneum to be obtained, as a result, there is a lower inflammatory
and cardiorespiratory repercussion for the patient
Patients will be selected from those who use the General Surgery Service of the Federal
Hospital of Bonsucesso for medical indication or own will, obeying the inclusion and
exclusion criteria. After signing the informed consent, they will be evaluated clinically
and laboratorially, according to the routine of preoperative exams and pre-anesthetic
outpatient evaluation. Patients will be allocated to one of two groups: control group (30
patients), who will receive pretreatment by venous infusion of saline solution; And
magnesium group (30 patients) who will receive pretreatment by intravenous infusion of
magnesium sulfate 60 mg / kg according to the random number sequence generated
electronically through the QuickCalcs program (GraphPad Software, San Diego, CA) Because it
is a double-blind study, both the researcher and the patient will not know which of the
groups will be studied.
The principal investigator will be responsible for the delivery of sealed envelope
containing the sequence of cases allocated in each of the groups to another anesthesiologist
who will prepare the solution (saline or magnesium sulphate) and will record in a specific
file in which group the volunteer was Allocated. Again the envelope will be sealed for
tabulation later, without the knowledge of the researcher. The same principal investigator
will be in charge of the measurement and recording of the data collected.
;
Allocation: Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05558969 -
The Effect of Magnesium Use in Reversal of Neuromuscular Block With Sugammadex
|
N/A | |
Completed |
NCT03168308 -
Sugammadex vs. Neostigmine for Neuromuscular Blockade Reversal in Thoracic Surgical Patients
|
Phase 4 | |
Not yet recruiting |
NCT03978780 -
Erector Spinae Block vs. Placebo Block Study
|
N/A | |
Completed |
NCT02912039 -
Electromyographic Assessment of the TetraGraph in Normal Volunteers
|
||
Completed |
NCT02892045 -
Mindray Neuromuscular Transmission Transducer
|
||
Completed |
NCT03427385 -
Minimum Local Anesthetic Dose for Adductor Canal Block
|
N/A | |
Completed |
NCT01450813 -
The Effect of Neuromuscular Blockade on the Composite Variability Index (CVI) During Laryngoscopy
|
N/A | |
Completed |
NCT00535496 -
Relation Between TOF-Watch® SX and a Peripheral Nerve Stimulator After 4.0 mg.Kg-1 Sugammadex (P05698)
|
Phase 3 | |
Recruiting |
NCT05794503 -
Postoperative Urinary Retention After Reversal of Neuromuscular Block by Neostigmine Versus Sugammadex
|
Early Phase 1 | |
Not yet recruiting |
NCT05993390 -
Pharmacological Reversal of Neuromuscular Blockade in Critically Ill Patients
|
N/A | |
Recruiting |
NCT04609410 -
Bleeding in Laparoscopic Liver Surgery
|
N/A | |
Terminated |
NCT03649672 -
The Validity and Tolerability of Awake Calibration of the TOF Watch SX Monitor
|
N/A | |
Completed |
NCT05474638 -
Comparison of Mechanomyographic 100 Versus 200 Hz 5 Second Tetanic Fade Ratios During Neuromuscular Block Recovery
|
N/A | |
Completed |
NCT05687253 -
Evaluation of Intubation Conditions Following BX1000 or Rocuronium in Subjects Undergoing Surgery
|
Phase 2 | |
Completed |
NCT05120999 -
Comparison of Onset of Neuromuscular Blockade With Electromyographic and Acceleromyographic Monitoring
|
||
Completed |
NCT03572413 -
The Effect of Low Pressure Pneumoperitoneum During Laparoscopic Colorectal Surgery on Innate Immune Homeostasis.
|
Phase 4 | |
Completed |
NCT03608436 -
The Effect of Low Pressure Pneumoperitoneum During Laparoscopic Colorectal Surgery on Early Quality of Recovery
|
Phase 4 | |
Recruiting |
NCT02930629 -
Residual Block in Postoperative Anaesthetic Care Unit
|
N/A | |
Completed |
NCT02932254 -
Magnesium Sulfate Effect Following the Reversal of Neuromuscular Blockade Induced by Rocuronium With Sugammadex
|
Phase 4 | |
Completed |
NCT01828385 -
Effect of Magnesium on the Recovery Time of Neuromuscular Blockade With Sugammadex
|
Phase 4 |