Diabetes Clinical Trial
Official title:
Epigenetic Alteration of Rho Guanine Nucleotide Exchange Factor 11 (ARHGEF11) in Cord Blood Samples in Macrosomia Exposed to Intrauterine Hyperglycaemia
Background Macrosomia at birth is associated with subsequent susceptibility to obesity,
abnormal glucose metabolism, hypertension and dyslipidaemia. Epigenetic reprogramming has
been reported to be involved in the development of human diseases caused by suboptimal
environmental or nutritional factors.
Objective The study was aiming to explore epigenetic mechanism influences on macrosomic
infants exposed to intrauterine hyperglycemia.
Design The investigators performed a genome-wide analysis of DNA methylation in cord blood
from macrosomic infants born to women with gestational diabetes or infants with normal birth
weight born to normal glucose-tolerant women in order to identify genes related to foetal
growth or early adipose tissue development. The candidate genes were then validated using
SEQUENOM MassARRAY after bisulfite conversion.
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