Lymphoma Clinical Trial
Official title:
BUSULFAN AND CYCLOPHOSPHAMIDE FOR CYTOREDUCTION OF PATIENTS WITH ACUTE AND CHRONIC LEUKEMIAS AND MYELODYSPLASTIC SYNDROMES UNDERGOING ALLOGENEIC BONE MARROW TRANSPLANTATION WHO CANNOT BE TREATED WITH TOTAL BODY IRRADIATION
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing
so they stop growing or die. Combining chemotherapy with bone marrow transplantation may
allow the doctor to give higher doses of chemotherapy drugs and kill more cancer cells.
PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy consisting of
busulfan and cyclophosphamide followed by bone marrow transplantation in treating patients
who have acute or chronic leukemia or myelodysplastic syndrome.
OBJECTIVES: I. Determine the effect of marrow ablation with high dose
busulfan/cyclophosphamide on engraftment, incidence of posttransplant relapse, incidence and
severity of graft versus host disease (GVHD), and incidence and severity of nonGVHD
posttransplant complications in patients with acute or chronic leukemia or myelodysplastic
syndrome who are eligible for allogeneic bone marrow transplants from HLA
identical/compatible donors but who cannot or should not receive total body irradiation as
part of their cytoreductive regimen.
OUTLINE: 2-Drug Combination Cytoreductive Chemotherapy followed by Bone Marrow Transplant
with, as indicated, CNS Prophylaxis. Busulfan, BU, NSC-750; Cyclophosphamide, CTX,
NSC-26271; followed by Allogeneic Bone Marrow, AlBM; with, as indicated, Intrathecal
Cytarabine, IT ARA-C, NSC-63878.
PROJECTED ACCRUAL: At least 15 patients will be accrued for this study.
;
Primary Purpose: Treatment
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