Clinical Trials Logo

Clinical Trial Summary

Lymphatic Anomalies (LA) is characterized by proliferation of lymphatic tissue causing deterioration of pulmonary function. Understanding changes in lymphatic anatomy in these patients is hindered by the difficulty of imaging the lymphatic system. Dynamic Contrast Enhanced MR Lymphangiogram (DCMRL) may be useful in investigating pathological changes in the lymphatic system.


Clinical Trial Description

Lymphatic anomalies (LA) are a spectrum of rare diseases classified into lymphatic tumors and malformations. Complicated LA cases in the past have been called lymphangiomatosis because of varied disseminated involvement including soft tissue and viscera such as the spleen, liver and bone. Pleural effusions and pericardial effusions are often associated with these lesions. These are now classified into different phenotypes such as Generalized Lymphatic Anomaly (GLA), Gorham's Stout Disease (GSD) and Kaposiform Lymphangiomatosis (KLA). These complicated phenotypes can cause massive osteolysis causing a morbidity and mortality from infection or paralysis or worsening pulmonary function and effusions (GSD, GLA, KLA).

The major cause of mortality and morbidity in these patients is the deterioration of pulmonary function by chronic chylous effusions and progressive interstitial lung disease. Unfortunately, little is known about biomarkers, risk stratification or the pathophysiology of this progression. The understanding of changes in patients' lymphatic anatomy with LA is hindered by the difficulty of imaging the lymphatic system. Dynamic Contrast Enhanced MR Lymphangiogram (DCMRL) is a technique that has recently been developed, allowing dynamic MR imaging of the lymphatic system by injecting gadolinium contrast agent in the groin lymph nodes.

This technique has been previously used to identify pathological lymphatic perfusion of the lung parenchyma in patients with plastic bronchitis and neonatal chylothorax. Based on these imaging findings, a treatment algorithm has been designed and used to successfully treat the majority of those patients with these conditions. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT02744027
Study type Interventional
Source Children's Hospital of Philadelphia
Contact
Status Completed
Phase N/A
Start date April 2016
Completion date December 2017

See also
  Status Clinical Trial Phase
Completed NCT02497131 - Study on the Role of Brentuximab Vedotin as Single Agent in the Treatment of Relapsed/Refractory CD30+ PTCL Patients Phase 2
Recruiting NCT01451502 - Infusion of Cell Populations From Unlicensed Umbilical Cord Blood Units N/A
Active, not recruiting NCT03264131 - BV-CHEP Chemotherapy for Adult T-cell Leukemia or Lymphoma Phase 2
Completed NCT03744676 - A Safety Trial of Lisocabtagene Maraleucel (JCAR017) for Relapsed and Refractory (R/R) B-cell Non-Hodgkin Lymphoma (NHL) in the Outpatient Setting (TRANSCEND-OUTREACH-007) Phase 2
Completed NCT02335242 - Sildenafil for the Treatment of Lymphatic Malformations Phase 2
Completed NCT03135535 - Micro-mobile Foot Compression and Diabetic Foot Phase 2
Active, not recruiting NCT05441943 - Lymphaticovenous Anastomosis as Treatment for Lymphedema N/A
Recruiting NCT06267807 - Lymphatic Phenotype in Noonan Syndrome Spectrum Disorders N/A
Withdrawn NCT05431179 - A Study of Zilovertamab and Ibrutinib in Patients With Relapsed or Refractory Mantle Cell Lymphoma Phase 3
Recruiting NCT05731141 - A Prospective Natural History Study of Lymphatic Anomalies
Recruiting NCT03696784 - Anti-CD19 CAR-T Cells With Inducible Caspase 9 Safety Switch for B-cell Lymphoma Phase 1
Completed NCT03709407 - "Effects of Manual Lymphatic Drainage in the Neck in Healthy Subjects. Experimental Randomized Crossover Study" N/A
Active, not recruiting NCT02663297 - Administration of T Lymphocytes for Prevention of Relapse of Lymphomas Phase 1
Completed NCT05683444 - Octreotide Improves Human Lymphatic Fluid Transport a Translational Trial Early Phase 1
Completed NCT02960841 - Effectiveness of Intracavitary Manual Lymphatic Drainage Phase 4
Recruiting NCT05263583 - Sepantronium Bromide for the Treatment of High-grade B-cell Lymphoma Phase 2
Terminated NCT02499627 - Bendamustine Plus Brentuximab Vedotin in HL and CD30+ PTCL in First Salvage Setting Phase 2
Recruiting NCT03373019 - Chidamide Combined With R-GDP in Treating Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma (DLBCL) Phase 2
Recruiting NCT03602157 - Study of CAR-T Cells Expressing CD30 and CCR4 for r/r CD30+ HL and CTCL Phase 1
Recruiting NCT02690545 - Study of CD30 CAR for Relapsed/Refractory CD30+ HL and CD30+ NHL Phase 1/Phase 2