Lung Tumor Clinical Trial
Official title:
GLUT1: A Novel Tool Reflecting Proliferative Activity of Lung Neuroendocrine Tumors
Lung neuroendocrine tumor (LNT) represents approximately 20% of all lung cancers. The
classification of LNT relies upon morphology. Recently, in the World Health Organization
(WHO) classification, Ki-67 rate has been proposed for classi fication. It is, however, known
that Ki-67 count has a poor interlaboratory reproducibly. For that reason, our team has
looked for a new biomarker.
GLUT1 protein a facilitative glucose transporter protein which has ubiquitous expression in
mammalian. GLUT1 is overexpressed in many human cancers. But, no study has evaluated the
GLUT1 staining as an aid diagnosis in LNT.
The team have assessed the GLUT1 immunohistochemical staining in 36 LNT and to assess its
diagnostic value.
The (LNT) Lung neuroendocrine tumor represents approximately 20% of all lung cancers. The
classification of LNT relies upon morphology. Recently, in the World Health Organization
(WHO) classification, Ki-67 rate has been proposed for classi fication. It is, however, known
that Ki-67 count has a poor interlaboratory reproducibly. For that reason, our team has
looked for a new biomarker.
GLUT1 protein a facilitative glucose transporter protein which has ubiquitous expression in
mammalian. GLUT1 is overexpressed in many human cancers. But, no study has evaluated the
GLUT1 staining as an aid diagnosis in LNT.
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