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Lung; Node clinical trials

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NCT ID: NCT05801406 Recruiting - Lung Cancer Clinical Trials

From Benchmark to Surgical Activity: the Role of Endobronchial Fiducial Markers for Ground Glass Lung Nodules Resection.

Vortex_US
Start date: March 24, 2023
Phase:
Study type: Observational [Patient Registry]

With the risen popularity of low-dose computed tomography (LDCT) for lung cancer screening, many patients present with peripheral pulmonary ground-glass nodules (GGNs) with a suspicious solid part. The appropriate diagnostic and management strategy for those lesions can be questionable. If malignancy is suspected, a surgical biopsy with the guidance of various localization methods available is recommended. Each localization method has its advantages and disadvantages. Therefore, it may not be possible to establish a gold standard for localizing indeterminate lung nodules since comparative clinical trials are lacking.

NCT ID: NCT05665504 Recruiting - Clinical trials for Adenocarcinoma of Lung

Using Biomarkers for Diagnosis, Risk Stratification of Post -Treatment Recurrence and Long-Term Surveillance of Lung Cancer

Start date: January 11, 2023
Phase:
Study type: Observational

This study is an observational study of blood and tissue biomarkers. Investigators plan to evaluate the accuracy of lung cancer biomarkers found in the blood in determining if a lung nodule is cancer or benign. Investigators also plan to examine another biomarker found in the tumor tissue to identify participants after lung cancer surgery who have a high risk for recurrent cancer. Finally, investigators plan to determine if one of the blood-based biomarkers can be used to detect any late cancer recurrence.

NCT ID: NCT05526573 Recruiting - Lung Cancer Clinical Trials

Diagnostic Yeld of Ultrathin Bronchoscopy in Peripheral Pulmonary Lesions

Start date: July 14, 2022
Phase:
Study type: Observational

The use of an ultrathin bronchoscope (UB) has recently been introduced in the diagnosis of peripheral lung lesions. The use of the UB can be supported by navigation systems such as fluoroscopy, ultrasound guidance, electromagnetic navigation, or other technologies, which have complementary potential. Further navigation techniques are still under study. The use of ultrathin instrumentation has already been shown to significantly reduce procedural times compared to traditional instrumentation. The purpose of the study is to prospectively evaluate the institutional experience of different third-level hospital centers with the use of a UB (MP190F; Olympus Medical Systems, Tokyo, Japan) for sampling peripheral lung lesions by means of transbronchial needle aspiration (TBNA) or transbronchial biopsy (TBB), performed after fluoroscopic navigation and simultaneous radial probe-endobronchial ultrasound (RP-EBUS) assessment. Design: multicentric, observational study.

NCT ID: NCT05463796 Recruiting - Lung Cancer Clinical Trials

InAdvance: Surveillance, Prevention, and Interception in a Population at Risk for Cancer

Start date: April 25, 2023
Phase:
Study type: Observational [Patient Registry]

This research study is creating a way to collect and store specimens and information from participants who may be at an increased risk of developing cancer, or has been diagnosed with an early phase of a cancer or a family member who has a family member with a precursor condition for cancer. - The objective of this study is to identify exposures as well as clinical, molecular, and pathological changes that can be used to predict early development of cancer, malignant transformation, and risks of progression to symptomatic cancer that can ultimately be fatal. - The ultimate goal is to identify novel markers of early detection and risk stratification to drive potential therapeutic approaches to intercept progression to cancer.

NCT ID: NCT05426135 Recruiting - Lung Cancer Clinical Trials

Artificial Intelligence System for Assessment of Tumor Risk and Diagnosis and Treatment

Start date: June 1, 2022
Phase:
Study type: Observational

To improve the accuracy of risk prediction, screening and treatment outcome of cancer, we aim to establish a medical database that includes standardized and structured clinical diagnosis and treatment information, image features, pathological features, and multi-omics information and to develop a multi-modal data fusion-based technology system using artificial intelligence technology based on database.

NCT ID: NCT05306912 Recruiting - Lung Cancer Clinical Trials

Molecular Analysis of Endoscopic Cytology Samples Supernatant in Pulmonary Nodules

KOBE
Start date: April 8, 2022
Phase: N/A
Study type: Interventional

Lung cancer screening is based on low dose CT scan (LDCT), a highly sensitive but poorly specific tool. Complementary specific approaches are thus strongly needed, among which cell-free DNA (cfDNA) genotyping has been proven highly specific but of low sensitivity (25 to 50% for stage I diseases) due to inconstant tumor shed. Tumor biopsy is thus often required and radial endobronchial ultrasound (rEBUS) bronchoscopy is a minimally invasive approach (<3% complications) but of limited sensitivity in cases of nodules < 20 mm. The investigators hypothesized that methylation analysis on cfDNA floating in supernatant derived from rEBUS specimens could improve rEBUS sensitivity

NCT ID: NCT04792632 Recruiting - Lung; Node Clinical Trials

Clinical Performance Evaluation of Veye Lung Nodules

CPEVLN
Start date: March 3, 2021
Phase:
Study type: Observational

Veye Lung Nodules (Aidence B.V., Amsterdam, the Netherlands) is a medical software device that is intended to assist radiologists with pulmonary nodule management on CT chest scans. This clinical trial aims to assess the clinical performance of Veye Lung nodules via a standalone performance evaluation and a reader study.

NCT ID: NCT04745962 Recruiting - Lung; Node Clinical Trials

Thin EBUS Pilot Study

Start date: September 9, 2020
Phase:
Study type: Observational

This is a single-center pilot study at the Medical University of South Carolina (MUSC) to evaluate the safety and efficacy of the TCP-EBUS scope (Thin EBUS). This study will consist of a standard of care bronchoscopy and will be followed for approximately 3 months. While the device is not FDA approved, it is the same technology but a thinner version of the SCP-EBUS bronchoscope.

NCT ID: NCT04005677 Recruiting - Clinical trials for Pulmonary Nodule, Solitary

The Early Diagnosis of Pulmonary Nodule Based on Multi-dimension Messages

Start date: July 1, 2018
Phase:
Study type: Observational

The researchers are aimed to investigate the early diagnosis of pulmonary nodule based on DNA, RNA, protein, metabolites through analyzing the serum, plasma, urine, faeces, peripheral blood mononuclear cell (PBMC), exhaled breath condensate and clinical characteristics.