Study of CVM-1118 for Patients With Advanced Neuroendocrine Tumors

Status Active, not recruiting

Clinical Trial Summary

CVM-1118 (TRX-818) is a new small molecule chemical entity being developed as a potential anti-cancer therapeutic by TaiRx, Inc. CVM-1118 is a potent anti-cancer agent in numerous human cancer cell lines. The safety of administrating CVM-1118 on human is evaluated from the phase 1 study. The objectives of the phase 2 study is to further investigate the efficacy of CVM-1118 for patients with advanced neuroendocrine tumors.

Clinical Trial Description

Neuroendocrine tumors (NETs) are a group of uncommon heterogeneous malignancies originating from neuroendocrine cells localized throughout the body. Approximately 50% of patients with NETs would have metastatic cancer, where 65% of patients with metastatic cancer would result in mortality within 5 years of diagnosis. The current treatments of NETs do not follow single discipline and the effective agents are largely still under clinical investigations. Apparent formation of vasculogenic mimicry (VM) has been reported in at least two types of NETs. Moreover, VM has been found as part of multiple microvascular alterations in mouse models of pancreatic neuroendocrine tumors. Wih the high potential of inhibiting VM formation, CVM-1118 is considered to have therapeutic potentials in treating NET tumors. ;

Study Design

Related Conditions & MeSH terms

Carcinoma, Neuroendocrine
Gastro-enteropancreatic Neuroendocrine Tumor
Lung Neuroendocrine Neoplasm
Neoplasms
Neuroendocrine Carcinoma
Neuroendocrine Tumors
Pancreatic Neuroendocrine Tumor

Clinical Trial Details

NCT number	NCT03600233
Study type	Interventional
Source	TaiRx, Inc.
Contact
Status	Active, not recruiting
Phase	Phase 2
Start date	December 15, 2018
Completion date	December 31, 2024

View Details

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