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NCT00558350 Clinical Trial

Systemic, Intrapulmonary and Pleural Inflammatory Reaction in Patients Undergoing Thoracic Surgery

Lung Neoplasms Clinical Trial

Official title:
Systemic, Intrapulmonary and Pleural Inflammatory Reaction in Patients Undergoing Thoracic Surgery

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00558350
Other study ID # 68/07
Secondary ID
Status Completed
Phase N/A
First received November 13, 2007
Last updated March 14, 2012
Start date April 2007
Est. completion date June 2011

Study information
Verified date March 2012
Source University Hospital, Basel, Switzerland
Contact n/a
Is FDA regulated No
Health authority Switzerland: Ethikkommission
Study type Observational

Clinical Trial Summary

Inflammatory reaction in different compartments of the body may have a negative effect on outcome. This study assesses the inflammatory reaction systemically, intrapulmonary and intrapleural by measuring different cytokines. Patients with lung cancer undergoing lobectomy or segmentectomy are included in the study. Hypothesis: The inflammatory reaction in the pleural space is high compared to the systemic and intrapulmonary ones.

Recruitment information / eligibility
Status Completed
Enrollment 15
Est. completion date June 2011
Est. primary completion date June 2011
Accepts healthy volunteers No
Gender Both
Age group 20 Years to 90 Years
Eligibility Inclusion Criteria:

- elective lobectomy

- elective segmentectomy

- 20-90 years

- informed consent given

Exclusion Criteria:

- emergency operations

- pneumonectomy

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
Switzerland University Hospital Basel Basel

Sponsors (1)
Lead Sponsor Collaborator
University Hospital, Basel, Switzerland

Country where clinical trial is conducted

Switzerland, 

Outcome
Type Measure Description Time frame Safety issue
Primary Cytokine levels in blood, bronchial lavage fluid and pleural fluid 2 years No
Primary Correlation between cytokine levels and pulmonary morbidity 2 years No
Secondary Comparison of this collective with transthoracic esophagectomies and evaluation of the inflammatory reactions (esophageal collective registered:NCT00512265) 4 years No
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